M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
1_MEVPQ 6_ PEPAP 11_ GSALS 16_ PAGVC 21_ GGAQR 26_ PGHLP 31_ GLLLG 36_ SHGLL 41_ GSPVR 46_ AAASS 51_ PVTTL 56_ TQTMH 61_ DLAGL 66_ GSETP 71_ KSQVG 76_ TLLFR 81_ SRSRL 86_ THLSL 91_ SRRAS 96_ ESSLS 101_ SESSE 106_ SSDAG 111_ LCMDS 116_ PSPMD 121_ PHMAE 126_ QTFEQ 131_ AIQAA 136_ SRIIR 141_ NEQFA 146_ IRRFQ 151_ SMPVR 156_ LLGHS 161_ PVLRN 166_ ITNSQ 171_ APDGR 176_ RKSEA 181_ GSGAA 186_ SSSGE 191_ DKEND 196_ GFVFK 201_ MPWKP 206_ THPSS 211_ THALA 216_ EWASR 221_ REAFA 226_ QRPSS 231_ APDLM 236_ CLSPD 241_ RKMEV 246_ EELSP 251_ LALGR 256_ FSLTP 261_ AEGDT 266_ EEDDG 271_ FVDIL 276_ ESDLK 281_ DDDAV 286_ PPGME 291_ SLISA 296_ PLVKT 301_ LEKEE 306_ EKDLV 311_ MYSKC 316_ QRLFR 321_ SPSMP 326_ CSVIR 331_ PILKR 336_ LERPQ 341_ DRDTP 346_ VQNKR 351_ RRSVT 356_ PPEEQ 361_ QEAEE 366_ PKARV 371_ LRSKS 376_ LCHDE 381_ IENLL 386_ DSDHR 391_ ELIGD 396_ YSKAF 401_ LLQTV 406_ DGKHQ 411_ DLKYI 416_ SPETM 421_ VALLT 426_ GKFSN 431_ IVDKF 436_ VIVDC 441_ RYPYE 446_ YEGGH 451_ IKTAV 456_ NLPLE 461_ RDAES 466_ FLLKS 471_ PIAPC 476_ SLDKR 481_ VILIF 486_ HCEFS 491_ SERGP 496_ RMCRF 501_ IRERD 506_ RAVND 511_ YPSLY 516_ YPEMY 521_ ILKGG 526_ YKEFF 531_ PQHPN 536_ FCEPQ 541_ DYRPM 546_ NHEAF 551_ KDELK 556_ TFRLK 561_ TRSWA 566_ GERSR 571_RELCS
1: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner (PubMed:17332740). The three isoforms seem to have a different level of activity (PubMed:1836978)