Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
1_MATNG 6_ SKVAD 11_ GQIST 16_ EVSEA 21_ PVAND 26_ KPKTL 31_ VVKVQ 36_ KKAAD 41_ LPDRD 46_ TWKGR 51_ FDFLM 56_ SCVGY 61_ AIGLG 66_ NVWRF 71_ PYLCG 76_ KNGGG 81_ AFLIP 86_ YFLTL 91_ IFAGV 96_ PLFLL 101_ ECSLG 106_ QYTSI 111_ GGLGV 116_ WKLAP 121_ MFKGV 126_ GLAAA 131_ VLSFW 136_ LNIYY 141_ IVIIS 146_ WAIYY 151_ LYNSF 156_ TTTLP 161_ WKQCD 166_ NPWNT 171_ DRCFS 176_ NYSMV 181_ NTTNM 186_ TSAVV 191_ EFWER 196_ NMHQM 201_ TDGLD 206_ KPGQI 211_ RWPLA 216_ ITLAI 221_ AWILV 226_ YFCIW 231_ KGVGW 236_ TGKVV 241_ YFSAT 246_ YPYIM 251_ LIILF 256_ FRGVT 261_ LPGAK 266_ EGILF 271_ YITPN 276_ FRKLS 281_ DSEVW 286_ LDAAT 291_ QIFFS 296_ YGLGL 301_ GSLIA 306_ LGSYN 311_ SFHNN 316_ VYRDS 321_ IIVCC 326_ INSCT 331_ SMFAG 336_ FVIFS 341_ IVGFM 346_ AHVTK 351_ RSIAD 356_ VAASG 361_ PGLAF 366_ LAYPE 371_ AVTQL 376_ PISPL 381_ WAILF 386_ FSMLL 391_ MLGID 396_ SQFCT 401_ VEGFI 406_ TALVD 411_ EYPRL 416_ LRNRR 421_ ELFIA 426_ AVCII 431_ SYLIG 436_ LSNIT 441_ QGGIY 446_ VFKLF 451_ DYYSA 456_ SGMSL 461_ LFLVF 466_ FECVS 471_ ISWFY 476_ GVNRF 481_ YDNIQ 486_ EMVGS 491_ RPCIW 496_ WKLCW 501_ SFFTP 506_ IIVAG 511_ VFIFS 516_ AVQMT 521_ PLTMG 526_ NYVFP 531_ KWGQG 536_ VGWLM 541_ ALSSM 546_ VLIPG 551_ YMAYM 556_ FLTLK 561_ GSLKQ 566_ RIQVM 571_ VQPSE 576_ DIVRP 581_ ENGPE 586_ QPQAG 591_SSTSK
1: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity)