Neuronal acetylcholine receptor subunit alpha-5
1_MAARG 6_ SGPRA 11_ LRLLL 16_ LVQLV 21_ AGRCG 26_ LAGAA 31_ GGAQR 36_ GLSEP 41_ SSIAK 46_ HEDSL 51_ LKDLF 56_ QDYER 61_ WVRPV 66_ EHLND 71_ KIKIK 76_ FGLAI 81_ SQLVD 86_ VDEKN 91_ QLMTT 96_ NVWLK 101_ QEWID 106_ VKLRW 111_ NPDDY 116_ GGIKV 121_ IRVPS 126_ DSVWT 131_ PDIVL 136_ FDNAD 141_ GRFEG 146_ TSTKT 151_ VIRYN 156_ GTVTW 161_ TPPAN 166_ YKSSC 171_ TIDVT 176_ FFPFD 181_ LQNCS 186_ MKFGS 191_ WTYDG 196_ SQVDI 201_ ILEDQ 206_ DVDKR 211_ DFFDN 216_ GEWEI 221_ VSATG 226_ SKGNR 231_ TDSCC 236_ WYPYV 241_ TYSFV 246_ IKRLP 251_ LFYTL 256_ FLIIP 261_ CIGLS 266_ FLTVL 271_ VFYLP 276_ SNEGE 281_ KICLC 286_ TSVLV 291_ SLTVF 296_ LLVIE 301_ EIIPS 306_ SSKVI 311_ PLIGE 316_ YLVFT 321_ MIFVT 326_ LSIMV 331_ TVFAI 336_ NIHHR 341_ SSSTH 346_ NAMAP 351_ LVRKI 356_ FLHTL 361_ PKLLC 366_ MRSHV 371_ DRYFT 376_ QKEET 381_ ESGSG 386_ PKSSR 391_ NTLEA 396_ ALDSI 401_ RYITR 406_ HIMKE 411_ NDVRE 416_ VVEDW 421_ KFIAQ 426_ VLDRM 431_ FLWTF 436_ LFVSI 441_ VGSLG 446_ LFVPV 451_ IYKWA 456_ NILIP 461_VHIGN
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:20881005, PubMed:8663494). Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit (PubMed:20881005, PubMed:8663494). Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4 (PubMed:20881005, PubMed:8663494). Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2 (PubMed:8663494). Plays a role in nicotine addiction (PubMed:20881005)