Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
1_MALND 6_ CFLLN 11_ LEVDH 16_ FMHCN 21_ ISSHS 26_ ADLPV 31_ NDDWS 36_ HPGIL 41_ YVIPA 46_ VYGVI 51_ ILIGL 56_ IGNIT 61_ LIKIF 66_ CTVKS 71_ MRNVP 76_ NLFIS 81_ SLALG 86_ DLLLL 91_ ITCAP 96_ VDASR 101_ YLADR 106_ WLFGR 111_ IGCKL 116_ IPFIQ 121_ LTSVG 126_ VSVFT 131_ LTALS 136_ ADRYK 141_ AIVRP 146_ MDIQA 151_ SHALM 156_ KICLK 161_ AAFIW 166_ IISML 171_ LAIPE 176_ AVFSD 181_ LHPFH 186_ EESTN 191_ QTFIS 196_ CAPYP 201_ HSNEL 206_ HPKIH 211_ SMASF 216_ LVFYV 221_ IPLSI 226_ ISVYY 231_ YFIAK 236_ NLIQS 241_ AYNLP 246_ VEGNI 251_ HVKKQ 256_ IESRK 261_ RLAKT 266_ VLVFV 271_ GLFAF 276_ CWLPN 281_ HVIYL 286_ YRSYH 291_ YSEVD 296_ TSMLH 301_ FVTSI 306_ CARLL 311_ AFTNS 316_ CVNPF 321_ ALYLL 326_ SKSFR 331_ KQFNT 336_ QLLCC 341_ QPGLI 346_ IRSHS 351_ TGRST 356_ TCMTS 361_ LKSTN 366_ PSVAT 371_ FSLIN 376_GNICH
1: Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity)