Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1)
1_MILNS 6_ STEDG 11_ IKRIQ 16_ DDCPK 21_ AGRHN 26_ YIFVM 31_ IPTLY 36_ SIIFV 41_ VGIFG 46_ NSLVV 51_ IVIYF 56_ YMKLK 61_ TVASV 66_ FLLNL 71_ ALADL 76_ CFLLT 81_ LPLWA 86_ VYTAM 91_ EYRWP 96_ FGNYL 101_ CKIAS 106_ ASVSF 111_ NLYAS 116_ VFLLT 121_ CLSID 126_ RYLAI 131_ VHPMK 136_ SRLRR 141_ TMLVA 146_ KVTCI 151_ IIWLL 156_ AGLAS 161_ LPAII 166_ HRNVF 171_ FIENT 176_ NITVC 181_ AFHYE 186_ SQNST 191_ LPIGL 196_ GLTKN 201_ ILGFL 206_ FPFLI 211_ ILTSY 216_ TLIWK 221_ ALKKA 226_ YEIQK 231_ NKPRN 236_ DDIFK 241_ IIMAI 246_ VLFFF 251_ FSWIP 256_ HQIFT 261_ FLDVL 266_ IQLGI 271_ IRDCR 276_ IADIV 281_ DTAMP 286_ ITICI 291_ AYFNN 296_ CLNPL 301_ FYGFL 306_ GKKFK 311_ RYFLQ 316_ LLKYI 321_ PPKAK 326_ SHSNL 331_ STKMS 336_ TLSYR 341_ PSDNV 346_ SSSTK 351_KPAPC
1: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106)
2: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis