Leukocyte elastase inhibitor (LEI) (Monocyte/neutrophil elastase inhibitor) (EI) (M/NEI) (Peptidase inhibitor 2) (PI-2) (Serpin B1)
1_MEQLS 6_ SANTR 11_ FALDL 16_ FLALS 21_ ENNPA 26_ GNIFI 31_ SPFSI 36_ SSAMA 41_ MVFLG 46_ TRGNT 51_ AAQLS 56_ KTFHF 61_ NTVEE 66_ VHSRF 71_ QSLNA 76_ DINKR 81_ GASYI 86_ LKLAN 91_ RLYGE 96_ KTYNF 101_ LPEFL 106_ VSTQK 111_ TYGAD 116_ LASVD 121_ FQHAS 126_ EDARK 131_ TINQW 136_ VKGQT 141_ EGKIP 146_ ELLAS 151_ GMVDN 156_ MTKLV 161_ LVNAI 166_ YFKGN 171_ WKDKF 176_ MKEAT 181_ TNAPF 186_ RLNKK 191_ DRKTV 196_ KMMYQ 201_ KKKFA 206_ YGYIE 211_ DLKCR 216_ VLELP 221_ YQGEE 226_ LSMVI 231_ LLPDD 236_ IEDES 241_ TGLKK 246_ IEEQL 251_ TLEKL 256_ HEWTK 261_ PENLD 266_ FIEVN 271_ VSLPR 276_ FKLEE 281_ SYTLN 286_ SDLAR 291_ LGVQD 296_ LFNSS 301_ KADLS 306_ GMSGA 311_ RDIFI 316_ SKIVH 321_ KSFVE 326_ VNEEG 331_ TEAAA 336_ ATAGI 341_ ATFCM 346_ LMPEE 351_ NFTAD 356_ HPFLF 361_ FIRHN 366_ SSGSI 371_LFLGR
1: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651)