Gene name: GCH1

Uniprot entry:

P30793

Protein names:

GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)

Protein sequence:

1_MEKGP 6_ VRAPA 11_ EKPRG 16_ ARCSN 21_ GFPER 26_ DPPRP 31_ GPSRP 36_ AEKPP 41_ RPEAK 46_ SAQPA 51_ DGWKG 56_ ERPRS 61_ EEDNE 66_ LNLPN 71_ LAAAY 76_ SSILS 81_ SLGEN 86_ PQRQG 91_ LLKTP 96_ WRAAS 101_ AMQFF 106_ TKGYQ 111_ ETISD 116_ VLNDA 121_ IFDED 126_ HDEMV 131_ IVKDI 136_ DMFSM 141_ CEHHL 146_ VPFVG 151_ KVHIG 156_ YLPNK 161_ QVLGL 166_ SKLAR 171_ IVEIY 176_ SRRLQ 181_ VQERL 186_ TKQIA 191_ VAITE 196_ ALRPA 201_ GVGVV 206_ VEATH 211_ MCMVM 216_ RGVQK 221_ MNSKT 226_ VTSTM 231_ LGVFR 236_ EDPKT 241_REEFL

Protein annotations

Protein functions:

1: Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown