Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)
1_MSKIS 6_ EAVKR 11_ ARAAF 16_ SSGRT 21_ RPLQF 26_ RIQQL 31_ EALQR 36_ LIQEQ 41_ EQELV 46_ GALAA 51_ DLHKN 56_ EWNAY 61_ YEEVV 66_ YVLEE 71_ IEYMI 76_ QKLPE 81_ WAADE 86_ PVEKT 91_ PQTQQ 96_ DELYI 101_ HSEPL 106_ GVVLV 111_ IGTWN 116_ YPFNL 121_ TIQPM 126_ VGAIA 131_ AGNSV 136_ VLKPS 141_ ELSEN 146_ MASLL 151_ ATIIP 156_ QYLDK 161_ DLYPV 166_ INGGV 171_ PETTE 176_ LLKER 181_ FDHIL 186_ YTGST 191_ GVGKI 196_ IMTAA 201_ AKHLT 206_ PVTLE 211_ LGGKS 216_ PCYVD 221_ KNCDL 226_ DVACR 231_ RIAWG 236_ KFMNS 241_ GQTCV 246_ APDYI 251_ LCDPS 256_ IQNQI 261_ VEKLK 266_ KSLKE 271_ FYGED 276_ AKKSR 281_ DYGRI 286_ ISARH 291_ FQRVM 296_ GLIEG 301_ QKVAY 306_ GGTGD 311_ AATRY 316_ IAPTI 321_ LTDVD 326_ PQSPV 331_ MQEEI 336_ FGPVL 341_ PIVCV 346_ RSLEE 351_ AIQFI 356_ NQREK 361_ PLALY 366_ MFSSN 371_ DKVIK 376_ KMIAE 381_ TSSGG 386_ VAAND 391_ VIVHI 396_ TLHSL 401_ PFGGV 406_ GNSGM 411_ GSYHG 416_ KKSFE 421_ TFSHR 426_ RSCLV 431_ RPLMN 436_ DEGLK 441_ VRYPP 446_SPAKM
1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)