Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)
1_MDMAD 6_ EPLNG 11_ SHTWL 16_ SIPFD 21_ LNGSV 26_ VSTNT 31_ SNQTE 36_ PYYDL 41_ TSNAV 46_ LTFIY 51_ FVVCI 56_ IGLCG 61_ NTLVI 66_ YVILR 71_ YAKMK 76_ TITNI 81_ YILNL 86_ AIADE 91_ LFMLG 96_ LPFLA 101_ MQVAL 106_ VHWPF 111_ GKAIC 116_ RVVMT 121_ VDGIN 126_ QFTSI 131_ FCLTV 136_ MSIDR 141_ YLAVV 146_ HPIKS 151_ AKWRR 156_ PRTAK 161_ MITMA 166_ VWGVS 171_ LLVIL 176_ PIMIY 181_ AGLRS 186_ NQWGR 191_ SSCTI 196_ NWPGE 201_ SGAWY 206_ TGFII 211_ YTFIL 216_ GFLVP 221_ LTIIC 226_ LCYLF 231_ IIIKV 236_ KSSGI 241_ RVGSS 246_ KRKKS 251_ EKKVT 256_ RMVSI 261_ VVAVF 266_ IFCWL 271_ PFYIF 276_ NVSSV 281_ SMAIS 286_ PTPAL 291_ KGMFD 296_ FVVVL 301_ TYANS 306_ CANPI 311_ LYAFL 316_ SDNFK 321_ KSFQN 326_ VLCLV 331_ KVSGT 336_ DDGER 341_ SDSKQ 346_ DKSRL 351_ NETTE 356_ TQRTL 361_LNGDL
1: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization