Neuronal acetylcholine receptor subunit beta-4
1_MRRAP 6_ SLVLF 11_ FLVAL 16_ CGRGN 21_ CRVAN 26_ AEEKL 31_ MDDLL 36_ NKTRY 41_ NNLIR 46_ PATSS 51_ SQLIS 56_ IKLQL 61_ SLAQL 66_ ISVNE 71_ REQIM 76_ TTNVW 81_ LKQEW 86_ TDYRL 91_ TWNSS 96_ RYEGV 101_ NILRI 106_ PAKRI 111_ WLPDI 116_ VLYNN 121_ ADGTY 126_ EVSVY 131_ TNLIV 136_ RSNGS 141_ VLWLP 146_ PAIYK 151_ SACKI 156_ EVKYF 161_ PFDQQ 166_ NCTLK 171_ FRSWT 176_ YDHTE 181_ IDMVL 186_ MTPTA 191_ SMDDF 196_ TPSGE 201_ WDIVA 206_ LPGRR 211_ TVNPQ 216_ DPSYV 221_ DVTYD 226_ FIIKR 231_ KPLFY 236_ TINLI 241_ IPCVL 246_ TTLLA 251_ ILVFY 256_ LPSDC 261_ GEKMT 266_ LCISV 271_ LLALT 276_ FFLLL 281_ ISKIV 286_ PPTSL 291_ DVPLI 296_ GKYLM 301_ FTMVL 306_ VTFSI 311_ VTSVC 316_ VLNVH 321_ HRSPS 326_ THTMA 331_ PWVKR 336_ CFLHK 341_ LPTFL 346_ FMKRP 351_ GPDSS 356_ PARAF 361_ PPSKS 366_ CVTKP 371_ EATAT 376_ STSPS 381_ NFYGN 386_ SMYFV 391_ NPASA 396_ ASKSP 401_ AGSTP 406_ VAIPR 411_ DFWLR 416_ SSGRF 421_ RQDVQ 426_ EALEG 431_ VSFIA 436_ QHMKN 441_ DDEDQ 446_ SVVED 451_ WKYVA 456_ MVVDR 461_ LFLWV 466_ FMFVC 471_ VLGTV 476_ GLFLP 481_ PLFQT 486_ HAASE 491_GPYAA
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:20881005, PubMed:31488329, PubMed:8663494, PubMed:8906617, PubMed:9203638). CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:11118490, PubMed:20881005, PubMed:8663494). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)