5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F)
1_MDFLN 6_ SSDQN 11_ LTSEE 16_ LLNRM 21_ PSKIL 26_ VSLTL 31_ SGLAL 36_ MTTTI 41_ NSLVI 46_ AAIIV 51_ TRKLH 56_ HPANY 61_ LICSL 66_ AVTDF 71_ LVAVL 76_ VMPFS 81_ IVYIV 86_ RESWI 91_ MGQVV 96_ CDIWL 101_ SVDIT 106_ CCTCS 111_ ILHLS 116_ AIALD 121_ RYRAI 126_ TDAVE 131_ YARKR 136_ TPKHA 141_ GIMIT 146_ IVWII 151_ SVFIS 156_ MPPLF 161_ WRHQG 166_ TSRDD 171_ ECIIK 176_ HDHIV 181_ STIYS 186_ TFGAF 191_ YIPLA 196_ LILIL 201_ YYKIY 206_ RAAKT 211_ LYHKR 216_ QASRI 221_ AKEEV 226_ NGQVL 231_ LESGE 236_ KSTKS 241_ VSTSY 246_ VLEKS 251_ LSDPS 256_ TDFDK 261_ IHSTV 266_ RSLRS 271_ EFKHE 276_ KSWRR 281_ QKISG 286_ TRERK 291_ AATTL 296_ GLILG 301_ AFVIC 306_ WLPFF 311_ VKELV 316_ VNVCD 321_ KCKIS 326_ EEMSN 331_ FLAWL 336_ GYLNS 341_ LINPL 346_ IYTIF 351_ NEDFK 356_ KAFQK 361_LVRCR
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:21422162, PubMed:8380639, PubMed:8384716). Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:34239069). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:34239069, PubMed:35610220)