Calcitonin receptor (CT-R)
1_MRFTF 6_ TSRCL 11_ ALFLL 16_ LNHPT 21_ PILPA 26_ FSNQT 31_ YPTIE 36_ PKPFL 41_ YVVGR 46_ KKMMD 51_ AQYKC 56_ YDRMQ 61_ QLPAY 66_ QGEGP 71_ YCNRT 76_ WDGWL 81_ CWDDT 86_ PAGVL 91_ SYQFC 96_ PDYFP 101_ DFDPS 106_ EKVTK 111_ YCDEK 116_ GVWFK 121_ HPENN 126_ RTWSN 131_ YTMCN 136_ AFTPE 141_ KLKNA 146_ YVLYY 151_ LAIVG 156_ HSLSI 161_ FTLVI 166_ SLGIF 171_ VFFRS 176_ LGCQR 181_ VTLHK 186_ NMFLT 191_ YILNS 196_ MIIII 201_ HLVEV 206_ VPNGE 211_ LVRRD 216_ PVSCK 221_ ILHFF 226_ HQYMM 231_ ACNYF 236_ WMLCE 241_ GIYLH 246_ TLIVV 251_ AVFTE 256_ KQRLR 261_ WYYLL 266_ GWGFP 271_ LVPTT 276_ IHAIT 281_ RAVYF 286_ NDNCW 291_ LSVET 296_ HLLYI 301_ IHGPV 306_ MAALV 311_ VNFFF 316_ LLNIV 321_ RVLVT 326_ KMRET 331_ HEAES 336_ HMYLK 341_ AVKAT 346_ MILVP 351_ LLGIQ 356_ FVVFP 361_ WRPSN 366_ KMLGK 371_ IYDYV 376_ MHSLI 381_ HFQGF 386_ FVATI 391_ YCFCN 396_ NEVQT 401_ TVKRQ 406_ WAQFK 411_ IQWNQ 416_ RWGRR 421_ PSNRS 426_ ARAAA 431_ AAAEA 436_ GDIPI 441_ YICHQ 446_ EPRNE 451_ PANNQ 456_ GEESA 461_ EIIPL 466_NIIEQ
1: G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35324283, PubMed:7476993)
2: Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993)