Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform)
1_MSATD 6_ RMGPR 11_ AVPGL 16_ RLALL 21_ LLLVL 26_ GTPKS 31_ GVQGQ 36_ EGLDF 41_ PEYDG 46_ VDRVI 51_ NVNAK 56_ NYKNV 61_ FKKYE 66_ VLALL 71_ YHEPP 76_ EDDKA 81_ SQRQF 86_ EMEEL 91_ ILELA 96_ AQVLE 101_ DKGVG 106_ FGLVD 111_ SEKDA 116_ AVAKK 121_ LGLTE 126_ VDSMY 131_ VFKGD 136_ EVIEY 141_ DGEFS 146_ ADTIV 151_ EFLLD 156_ VLEDP 161_ VELIE 166_ GEREL 171_ QAFEN 176_ IEDEI 181_ KLIGY 186_ FKSKD 191_ SEHYK 196_ AFEDA 201_ AEEFH 206_ PYIPF 211_ FATFD 216_ SKVAK 221_ KLTLK 226_ LNEID 231_ FYEAF 236_ MEEPV 241_ TIPDK 246_ PNSEE 251_ EIVNF 256_ VEEHR 261_ RSTLR 266_ KLKPE 271_ SMYET 276_ WEDDM 281_ DGIHI 286_ VAFAE 291_ EADPD 296_ GFEFL 301_ ETLKA 306_ VAQDN 311_ TENPD 316_ LSIIW 321_ IDPDD 326_ FPLLV 331_ PYWEK 336_ TFDID 341_ LSAPQ 346_ IGVVN 351_ VTDAD 356_ SVWME 361_ MDDEE 366_ DLPSA 371_ EELED 376_ WLEDV 381_ LEGEI 386_ NTEDD 391_DDDDD
1: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (PubMed:27185316)