Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8) (EC 1.14.14.73) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) (EC 1.14.13.148)
1_MGKKV 6_ AIIGA 11_ GVSGL 16_ ASIRS 21_ CLEEG 26_ LEPTC 31_ FEKSN 36_ DIGGL 41_ WKFSD 46_ HAEEG 51_ RASIY 56_ KSVFS 61_ NSSKE 66_ MMCFP 71_ DFPFP 76_ DDFPN 81_ FMHNS 86_ KIQEY 91_ IIAFA 96_ KEKNL 101_ LKYIQ 106_ FKTFV 111_ SSVNK 116_ HPDFA 121_ TTGQW 126_ DVTTE 131_ RDGKK 136_ ESAVF 141_ DAVMV 146_ CSGHH 151_ VYPNL 156_ PKESF 161_ PGLNH 166_ FKGKC 171_ FHSRD 176_ YKEPG 181_ VFNGK 186_ RVLVV 191_ GLGNS 196_ GCDIA 201_ TELSR 206_ TAEQV 211_ MISSR 216_ SGSWV 221_ MSRVW 226_ DNGYP 231_ WDMLL 236_ VTRFG 241_ TFLKN 246_ NLPTA 251_ ISDWL 256_ YVKQM 261_ NARFK 266_ HENYG 271_ LMPLN 276_ GVLRK 281_ EPVFN 286_ DELPA 291_ SILCG 296_ IVSVK 301_ PNVKE 306_ FTETS 311_ AIFED 316_ GTIFE 321_ GIDCV 326_ IFATG 331_ YSFAY 336_ PFLDE 341_ SIIKS 346_ RNNEI 351_ ILFKG 356_ VFPPL 361_ LEKST 366_ IAVIG 371_ FVQSL 376_ GAAIP 381_ TVDLQ 386_ SRWAA 391_ QVIKG 396_ TCTLP 401_ SMEDM 406_ MNDIN 411_ EKMEK 416_ KRKWF 421_ GKSET 426_ IQTDY 431_ IVYMD 436_ ELSSF 441_ IGAKP 446_ NIPWL 451_ FLTDP 456_ KLAME 461_ VYFGP 466_ CSPYQ 471_ FRLVG 476_ PGQWP 481_ GARNA 486_ ILTQW 491_ DRSLK 496_ PMQTR 501_ VVGRL 506_ QKPCF 511_ FFHWL 516_ KLFAI 521_ PILLI 526_AVFLV
1: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269)