Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2)
1_MEEHT 6_ EAGSA 11_ PEMGA 16_ QKALI 21_ DNPAD 26_ ILVIA 31_ AYFLL 36_ VIGVG 41_ LWSMC 46_ RTNRG 51_ TVGGY 56_ FLAGR 61_ SMVWW 66_ PVGAS 71_ LFASN 76_ IGSGH 81_ FVGLA 86_ GTGAA 91_ SGLAV 96_ AGFEW 101_ NALFV 106_ VLLLG 111_ WLFAP 116_ VYLTA 121_ GVITM 126_ PQYLR 131_ KRFGG 136_ RRIRL 141_ YLSVL 146_ SLFLY 151_ IFTKI 156_ SVDMF 161_ SGAVF 166_ IQQAL 171_ GWNIY 176_ ASVIA 181_ LLGIT 186_ MIYTV 191_ TGGLA 196_ ALMYT 201_ DTVQT 206_ FVILG 211_ GACIL 216_ MGYAF 221_ HEVGG 226_ YSGLF 231_ DKYLG 236_ AATSL 241_ TVSED 246_ PAVGN 251_ ISSFC 256_ YRPRP 261_ DSYHL 266_ LRHPV 271_ TGDLP 276_ WPALL 281_ LGLTI 286_ VSGWY 291_ WCSDQ 296_ VIVQR 301_ CLAGK 306_ SLTHI 311_ KAGCI 316_ LCGYL 321_ KLTPM 326_ FLMVM 331_ PGMIS 336_ RILYP 341_ DEVAC 346_ VVPEV 351_ CRRVC 356_ GTEVG 361_ CSNIA 366_ YPRLV 371_ VKLMP 376_ NGLRG 381_ LMLAV 386_ MLAAL 391_ MSSLA 396_ SIFNS 401_ SSTLF 406_ TMDIY 411_ TRLRP 416_ RAGDR 421_ ELLLV 426_ GRLWV 431_ VFIVV 436_ VSVAW 441_ LPVVQ 446_ AAQGG 451_ QLFDY 456_ IQAVS 461_ SYLAP 466_ PVSAV 471_ FVLAL 476_ FVPRV 481_ NEQGA 486_ FWGLI 491_ GGLLM 496_ GLARL 501_ IPEFS 506_ FGSGS 511_ CVQPS 516_ ACPAF 521_ LCGVH 526_ YLYFA 531_ IVLFF 536_ CSGLL 541_ TLTVS 546_ LCTAP 551_ IPRKH 556_ LHRLV 561_ FSLRH 566_ SKEER 571_ EDLDA 576_ DEQQG 581_ SSLPV 586_ QNGCP 591_ ESAME 596_ MNEPQ 601_ APAPS 606_ LFRQC 611_ LLWFC 616_ GMSRG 621_ GVGSP 626_ PPLTQ 631_ EEAAA 636_ AARRL 641_ EDISE 646_ DPSWA 651_ RVVNL 656_ NALLM 661_ MAVAV 666_FLWGF
1: Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (PubMed:37217492). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity)