Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5)
1_MDNGM 6_ FSGFI 11_ MIKNL 16_ LLFCI 21_ SMNLS 26_ SHFGF 31_ SQMPT 36_ SSVKD 41_ ETNDN 46_ ITIFT 51_ RILDG 56_ LLDGY 61_ DNRLR 66_ PGLGE 71_ RITQV 76_ RTDIY 81_ VTSFG 86_ PVSDT 91_ EMEYT 96_ IDVFF 101_ RQSWK 106_ DERLR 111_ FKGPM 116_ QRLPL 121_ NNLLA 126_ SKIWT 131_ PDTFF 136_ HNGKK 141_ SIAHN 146_ MTTPN 151_ KLLRL 156_ EDDGT 161_ LLYTM 166_ RLTIS 171_ AECPM 176_ QLEDF 181_ PMDAH 186_ ACPLK 191_ FGSYA 196_ YPNSE 201_ VVYVW 206_ TNGST 211_ KSVVV 216_ AEDGS 221_ RLNQY 226_ HLMGQ 231_ TVGTE 236_ NISTS 241_ TGEYT 246_ IMTAH 251_ FHLKR 256_ KIGYF 261_ VIQTY 266_ LPCIM 271_ TVILS 276_ QVSFW 281_ LNRES 286_ VPART 291_ VFGVT 296_ TVLTM 301_ TTLSI 306_ SARNS 311_ LPKVA 316_ YATAM 321_ DWFIA 326_ VCYAF 331_ VFSAL 336_ IEFAT 341_ VNYFT 346_ KRGWA 351_ WDGKK 356_ ALEAA 361_ KIKKK 366_ REVIL 371_ NKSTN 376_ AFTTG 381_ KMSHP 386_ PNIPK 391_ EQTPA 396_ GTSNT 401_ TSVSV 406_ KPSEE 411_ KTSES 416_ KKTYN 421_ SISKI 426_ DKMSR 431_ IVFPV 436_ LFGTF 441_ NLVYW 446_ ATYLN 451_ REPVI 456_KGAAS
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:29961870, PubMed:30140029, PubMed:31056671). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30140029). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:14993607, PubMed:30140029). GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity)