Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)
1_MAASV 6_ VCRAA 11_ TAGAQ 16_ VLLRA 21_ RRSPA 26_ LLRTP 31_ ALRST 36_ ATFAQ 41_ ALQFV 46_ PETQV 51_ SLLDN 56_ GLRVA 61_ SEQSS 66_ QPTCT 71_ VGVWI 76_ DVGSR 81_ FETEK 86_ NNGAG 91_ YFLEH 96_ LAFKG 101_ TKNRP 106_ GSALE 111_ KEVES 116_ MGAHL 121_ NAYST 126_ REHTA 131_ YYIKA 136_ LSKDL 141_ PKAVE 146_ LLGDI 151_ VQNCS 156_ LEDSQ 161_ IEKER 166_ DVILR 171_ EMQEN 176_ DASMR 181_ DVVFN 186_ YLHAT 191_ AFQGT 196_ PLAQA 201_ VEGPS 206_ ENVRK 211_ LSRAD 216_ LTEYL 221_ STHYK 226_ APRMV 231_ LAAAG 236_ GVEHQ 241_ QLLDL 246_ AQKHL 251_ GGIPW 256_ TYAED 261_ AVPTL 266_ TPCRF 271_ TGSEI 276_ RHRDD 281_ ALPFA 286_ HVAIA 291_ VEGPG 296_ WASPD 301_ NVALQ 306_ VANAI 311_ IGHYD 316_ CTYGG 321_ GVHLS 326_ SPLAS 331_ GAVAN 336_ KLCQS 341_ FQTFS 346_ ICYAE 351_ TGLLG 356_ AHFVC 361_ DRMKI 366_ DDMMF 371_ VLQGQ 376_ WMRLC 381_ TSATE 386_ SEVAR 391_ GKNIL 396_ RNALV 401_ SHLDG 406_ TTPVC 411_ EDIGR 416_ SLLTY 421_ GRRIP 426_ LAEWE 431_ SRIAE 436_ VDASV 441_ VREIC 446_ SKYIY 451_ DQCPA 456_ VAGYG 461_ PIEQL 466_ PDYNR 471_IRSGM
1: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179)