Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]
1_MAPGQ 6_ LALFS 11_ VSDKT 16_ GLVEF 21_ ARNLT 26_ ALGLN 31_ LVASG 36_ GTAKA 41_ LRDAG 46_ LAVRD 51_ VSELT 56_ GFPEM 61_ LGGRV 66_ KTLHP 71_ AVHAG 76_ ILARN 81_ IPEDN 86_ ADMAR 91_ LDFNL 96_ IRVVA 101_ CNLYP 106_ FVKTV 111_ ASPGV 116_ TVEEA 121_ VEQID 126_ IGGVT 131_ LLRAA 136_ AKNHA 141_ RVTVV 146_ CEPED 151_ YVVVS 156_ TEMQS 161_ SESKD 166_ TSLET 171_ RRQLA 176_ LKAFT 181_ HTAQY 186_ DEAIS 191_ DYFRK 196_ QYSKG 201_ VSQMP 206_ LRYGM 211_ NPHQT 216_ PAQLY 221_ TLQPK 226_ LPITV 231_ LNGAP 236_ GFINL 241_ CDALN 246_ AWQLV 251_ KELKE 256_ ALGIP 261_ AAASF 266_ KHVSP 271_ AGAAV 276_ GIPLS 281_ EDEAK 286_ VCMVY 291_ DLYKT 296_ LTPIS 301_ AAYAR 306_ ARGAD 311_ RMSSF 316_ GDFVA 321_ LSDVC 326_ DVPTA 331_ KIISR 336_ EVSDG 341_ IIAPG 346_ YEEEA 351_ LTILS 356_ KKKNG 361_ NYCVL 366_ QMDQS 371_ YKPDE 376_ NEVRT 381_ LFGLH 386_ LSQKR 391_ NNGVV 396_ DKSLF 401_ SNVVT 406_ KNKDL 411_ PESAL 416_ RDLIV 421_ ATIAV 426_ KYTQS 431_ NSVCY 436_ AKNGQ 441_ VIGIG 446_ AGQQS 451_ RIHCT 456_ RLAGD 461_ KANYW 466_ WLRHH 471_ PQVLS 476_ MKFKT 481_ GVKRA 486_ EISNA 491_ IDQYV 496_ TGTIG 501_ EDEDL 506_ IKWKA 511_ LFEEV 516_ PELLT 521_ EAEKK 526_ EWVEK 531_ LTEVS 536_ ISSDA 541_ FFPFR 546_ DNVDR 551_ AKRSG 556_ VAYIA 561_ APSGS 566_ AADKV 571_ VIEAC 576_ DELGI 581_ ILAHT 586_NLRLF
1: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)