Gene name: APOBEC3A

Uniprot entry:

P31941

Protein names:

DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1)

Protein sequence:

1_MEASP 6_ ASGPR 11_ HLMDP 16_ HIFTS 21_ NFNNG 26_ IGRHK 31_ TYLCY 36_ EVERL 41_ DNGTS 46_ VKMDQ 51_ HRGFL 56_ HNQAK 61_ NLLCG 66_ FYGRH 71_ AELRF 76_ LDLVP 81_ SLQLD 86_ PAQIY 91_ RVTWF 96_ ISWSP 101_ CFSWG 106_ CAGEV 111_ RAFLQ 116_ ENTHV 121_ RLRIF 126_ AARIY 131_ DYDPL 136_ YKEAL 141_ QMLRD 146_ AGAQV 151_ SIMTY 156_ DEFKH 161_ CWDTF 166_ VDHQG 171_ CPFQP 176_ WDGLD 181_ EHSQA 186_ LSGRL 191_RAILQ

Protein annotations

Protein functions:

1: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation