Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
1_MSNPR 6_ SLEEE 11_ KYDMS 16_ GARLA 21_ LILCV 26_ TKARE 31_ GSEED 36_ LDALE 41_ HMFRQ 46_ LRFES 51_ TMKRD 56_ PTAEQ 61_ FQEEL 66_ EKFQQ 71_ AIDSR 76_ EDPVS 81_ CAFVV 86_ LMAHG 91_ REGFL 96_ KGEDG 101_ EMVKL 106_ ENLFE 111_ ALNNK 116_ NCQAL 121_ RAKPK 126_ VYIIQ 131_ ACRGE 136_ QRDPG 141_ ETVGG 146_ DEIVM 151_ VIKDS 156_ PQTIP 161_ TYTDA 166_ LHVYS 171_ TVEGY 176_ IAYRH 181_ DQKGS 186_ CFIQT 191_ LVDVF 196_ TKRKG 201_ HILEL 206_ LTEVT 211_ RRMAE 216_ AELVQ 221_ EGKAR 226_ KTNPE 231_ IQSTL 236_RKRLY
1: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736)