14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
1_MTMDK 6_ SELVQ 11_ KAKLA 16_ EQAER 21_ YDDMA 26_ AAMKA 31_ VTEQG 36_ HELSN 41_ EERNL 46_ LSVAY 51_ KNVVG 56_ ARRSS 61_ WRVIS 66_ SIEQK 71_ TERNE 76_ KKQQM 81_ GKEYR 86_ EKIEA 91_ ELQDI 96_ CNDVL 101_ ELLDK 106_ YLIPN 111_ ATQPE 116_ SKVFY 121_ LKMKG 126_ DYFRY 131_ LSEVA 136_ SGDNK 141_ QTTVS 146_ NSQQA 151_ YQEAF 156_ EISKK 161_ EMQPT 166_ HPIRL 171_ GLALN 176_ FSVFY 181_ YEILN 186_ SPEKA 191_ CSLAK 196_ TAFDE 201_ AIAEL 206_ DTLNE 211_ ESYKD 216_ STLIM 221_ QLLRD 226_ NLTLW 231_ TSENQ 236_ GDEGD 241_AGEGE
1: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13