14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
1_MERAS 6_ LIQKA 11_ KLAEQ 16_ AERYE 21_ DMAAF 26_ MKGAV 31_ EKGEE 36_ LSCEE 41_ RNLLS 46_ VAYKN 51_ VVGGQ 56_ RAAWR 61_ VLSSI 66_ EQKSN 71_ EEGSE 76_ EKGPE 81_ VREYR 86_ EKVET 91_ ELQGV 96_ CDTVL 101_ GLLDS 106_ HLIKE 111_ AGDAE 116_ SRVFY 121_ LKMKG 126_ DYYRY 131_ LAEVA 136_ TGDDK 141_ KRIID 146_ SARSA 151_ YQEAM 156_ DISKK 161_ EMPPT 166_ NPIRL 171_ GLALN 176_ FSVFH 181_ YEIAN 186_ SPEEA 191_ ISLAK 196_ TTFDE 201_ AMADL 206_ HTLSE 211_ DSYKD 216_ STLIM 221_ QLLRD 226_ NLTLW 231_ TADNA 236_ GEEGG 241_EAPQE
1: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127)