Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
1_MGILS 6_ FLPVL 11_ ATESD 16_ WADCK 21_ SPQPW 26_ GHMLL 31_ WTAVL 36_ FLAPV 41_ AGTPA 46_ APPKA 51_ VLKLE 56_ PQWIN 61_ VLQED 66_ SVTLT 71_ CRGTH 76_ SPESD 81_ SIQWF 86_ HNGNL 91_ IPTHT 96_ QPSYR 101_ FKANN 106_ NDSGE 111_ YTCQT 116_ GQTSL 121_ SDPVH 126_ LTVLS 131_ EWLVL 136_ QTPHL 141_ EFQEG 146_ ETIVL 151_ RCHSW 156_ KDKPL 161_ VKVTF 166_ FQNGK 171_ SKKFS 176_ RSDPN 181_ FSIPQ 186_ ANHSH 191_ SGDYH 196_ CTGNI 201_ GYTLY 206_ SSKPV 211_ TITVQ 216_ APSSS 221_ PMGII 226_ VAVVT 231_ GIAVA 236_ AIVAA 241_ VVALI 246_ YCRKK 251_ RISAL 256_ PGYPE 261_ CREMG 266_ ETLPE 271_ KPANP 276_ TNPDE 281_ ADKVG 286_ AENTI 291_ TYSLL 296_ MHPDA 301_LEEPD
1: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis