Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
1_MDQSV 6_ AIQET 11_ LAEGE 16_ YCVIA 21_ VQGVL 26_ CEGDS 31_ RQSRL 36_ LGLVR 41_ YRLEH 46_ GGQEH 51_ ALFLY 56_ THRRM 61_ AITGD 66_ DVSLD 71_ QIVPV 76_ SRDFT 81_ LEEVS 86_ PDGEL 91_ YILGS 96_ DVTVQ 101_ LDTAE 106_ LSLVF 111_ QLPFG 116_ SQTRM 121_ FLHEV 126_ ARACP 131_ GFDSA 136_ TRDPE 141_ FLWLS 146_ RYRCA 151_ ELELE 156_ MPTPR 161_ GCNSA 166_ LVTWP 171_ GYATI 176_ GGGRY 181_ PSRKK 186_ RWGLE 191_ EARPQ 196_ GAGSV 201_ LFWGG 206_ AMEKT 211_ GFRLM 216_ ERAHG 221_ GGFVW 226_ GRSAR 231_ DGRRD 236_ EELEE 241_ AGREM 246_ SAAAG 251_ SRERN 256_ TAGGS 261_ NFDGL 266_ RPNGK 271_ GVPMD 276_ QSSRG 281_ QDKPE 286_ SLQPR 291_ QNKSK 296_ SEITD 301_ MVRSS 306_ TITVS 311_ DKAHI 316_ LSMQK 321_ FGLRD 326_ TIVKS 331_ HLLQK 336_ EEDYT 341_ YIQNF 346_ RFFAG 351_ TYNVN 356_ GQSPK 361_ ECLRL 366_ WLSNG 371_ IQAPD 376_ VYCVG 381_ FQELD 386_ LSKEA 391_ FFFHD 396_ TPKEE 401_ EWFKA 406_ VSEGL 411_ HPDAK 416_ YAKVK 421_ LIRLV 426_ GIMLL 431_ LYVKQ 436_ EHAAY 441_ ISEVE 446_ AETVG 451_ TGIMG 456_ RMGNK 461_ GGVAI 466_ RFQFH 471_ NTSIC 476_ VVNSH 481_ LAAHI 486_ EEYER 491_ RNQDY 496_ KDICS 501_ RMQFC 506_ QPDPS 511_ LPPLT 516_ ISNHD 521_ VILWL 526_ GDLNY 531_ RIEEL 536_ DVEKV 541_ KKLIE 546_ EKDFQ 551_ MLYAY 556_ DQLKI 561_ QVAAK 566_ TVFEG 571_ FTEGE 576_ LTFQP 581_ TYKYD 586_ TGSDD 591_ WDTSE 596_ KCRAP 601_ AWCDR 606_ ILWKG 611_ KNITQ 616_ LSYQS 621_ HMALK 626_ TSDHK 631_ PVSSV 636_ FDIGV 641_ RVVND 646_ ELYRK 651_ TLEEI 656_ VRSLD 661_ KMENA 666_ NIPSV 671_ SLSKR 676_ EFCFQ 681_ NVKYM 686_ QLKVE 691_ SFTIH 696_ NGQVP 701_ CHFEF 706_ INKPD 711_ EESYC 716_ KQWLN 721_ ANPSR 726_ GFLLP 731_ DSDVE 736_ IDLEL 741_ FVNKM 746_ TATKL 751_ NSGED 756_ KIEDI 761_ LVLHL 766_ DRGKD 771_ YFLSV 776_ SGNYL 781_ PSCFG 786_ SPIHT 791_ LCYMR 796_ EPILD 801_ LPLET 806_ ISELT 811_ LMPVW 816_ TGDDG 821_ SQLDS 826_ PMEIP 831_ KELWM 836_ MVDYL 841_ YRNAV 846_ QQEDL 851_ FQQPG 856_ LRSEF 861_ EHIRD 866_ CLDTG 871_ MIDNL 876_ SASNH 881_ SVAEA 886_ LLLFL 891_ ESLPE 896_ PVICY 901_ STYHN 906_ CLECS 911_ GNYTA 916_ SKQVI 921_ STLPI 926_ FHKNV 931_ FHYLM 936_ AFLRE 941_ LLKNS 946_ AKNHL 951_ DENIL 956_ ASIFG 961_ SLLLR 966_ NPAGH 971_ QKLDM 976_ TEKKK 981_ AQEFI 986_HQFLC
1: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events