Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
1_MELLK 6_ LNRSV 11_ QGTGP 16_ GPGAS 21_ LCRPG 26_ APLLN 31_ SSSVG 36_ NLSCE 41_ PPRIR 46_ GAGTR 51_ ELELA 56_ IRITL 61_ YAVIF 66_ LMSVG 71_ GNMLI 76_ IVVLG 81_ LSRRL 86_ RTVTN 91_ AFLLS 96_ LAVSD 101_ LLLAV 106_ ACMPF 111_ TLLPN 116_ LMGTF 121_ IFGTV 126_ ICKAV 131_ SYLMG 136_ VSVSV 141_ STLSL 146_ VAIAL 151_ ERYSA 156_ ICRPL 161_ QARVW 166_ QTRSH 171_ AARVI 176_ VATWL 181_ LSGLL 186_ MVPYP 191_ VYTVV 196_ QPVGP 201_ RVLQC 206_ VHRWP 211_ SARVR 216_ QTWSV 221_ LLLLL 226_ LFFIP 231_ GVVMA 236_ VAYGL 241_ ISREL 246_ YLGLR 251_ FDGDS 256_ DSDSQ 261_ SRVRN 266_ QGGLP 271_ GAVHQ 276_ NGRCR 281_ PETGA 286_ VGEDS 291_ DGCYV 296_ QLPRS 301_ RPALE 306_ LTALT 311_ APGPG 316_ SGSRP 321_ TQAKL 326_ LAKKR 331_ VVRML 336_ LVIVV 341_ LFFLC 346_ WLPVY 351_ SANTW 356_ RAFDG 361_ PGAHR 366_ ALSGA 371_ PISFI 376_ HLLSY 381_ ASACV 386_ NPLVY 391_ CFMHR 396_ RFRQA 401_ CLETC 406_ ARCCP 411_ RPPRA 416_ RPRAL 421_ PDEDP 426_ PTPSI 431_ ASLSR 436_ LSYTT 441_ISTLG
1: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
2: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism