Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)
1_MRPPS 6_ PLPAR 11_ WLCVL 16_ AGALA 21_ WALGP 26_ AGGQA 31_ ARLQE 36_ ECDYV 41_ QMIEV 46_ QHKQC 51_ LEEAQ 56_ LENET 61_ IGCSK 66_ MWDNL 71_ TCWPA 76_ TPRGQ 81_ VVVLA 86_ CPLIF 91_ KLFSS 96_ IQGRN 101_ VSRSC 106_ TDEGW 111_ THLEP 116_ GPYPI 121_ ACGLD 126_ DKAAS 131_ LDEQQ 136_ TMFYG 141_ SVKTG 146_ YTIGY 151_ GLSLA 156_ TLLVA 161_ TAILS 166_ LFRKL 171_ HCTRN 176_ YIHMH 181_ LFISF 186_ ILRAA 191_ AVFIK 196_ DLALF 201_ DSGES 206_ DQCSE 211_ GSVGC 216_ KAAMV 221_ FFQYC 226_ VMANF 231_ FWLLV 236_ EGLYL 241_ YTLLA 246_ VSFFS 251_ ERKYF 256_ WGYIL 261_ IGWGV 266_ PSTFT 271_ MVWTI 276_ ARIHF 281_ EDYGC 286_ WDTIN 291_ SSLWW 296_ IIKGP 301_ ILTSI 306_ LVNFI 311_ LFICI 316_ IRILL 321_ QKLRP 326_ PDIRK 331_ SDSSP 336_ YSRLA 341_ RSTLL 346_ LIPLF 351_ GVHYI 356_ MFAFF 361_ PDNFK 366_ PEVKM 371_ VFELV 376_ VGSFQ 381_ GFVVA 386_ ILYCF 391_ LNGEV 396_ QAELR 401_ RKWRR 406_ WHLQG 411_ VLGWN 416_ PKYRH 421_ PSGGS 426_ NGATC 431_ STQVS 436_ MLTRV 441_ SPGAR 446_ RSSSF 451_QAEVS
1: G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed:8179610). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38 (PubMed:35477937, PubMed:8179610). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35477937, PubMed:36385145, PubMed:8179610)