Melanocortin receptor 4 (MC4-R)
1_MVNST 6_ HRGMH 11_ TSLHL 16_ WNRSS 21_ YRLHS 26_ NASES 31_ LGKGY 36_ SDGGC 41_ YEQLF 46_ VSPEV 51_ FVTLG 56_ VISLL 61_ ENILV 66_ IVAIA 71_ KNKNL 76_ HSPMY 81_ FFICS 86_ LAVAD 91_ MLVSV 96_ SNGSE 101_ TIVIT 106_ LLNST 111_ DTDAQ 116_ SFTVN 121_ IDNVI 126_ DSVIC 131_ SSLLA 136_ SICSL 141_ LSIAV 146_ DRYFT 151_ IFYAL 156_ QYHNI 161_ MTVKR 166_ VGIII 171_ SCIWA 176_ ACTVS 181_ GILFI 186_ IYSDS 191_ SAVII 196_ CLITM 201_ FFTML 206_ ALMAS 211_ LYVHM 216_ FLMAR 221_ LHIKR 226_ IAVLP 231_ GTGAI 236_ RQGAN 241_ MKGAI 246_ TLTIL 251_ IGVFV 256_ VCWAP 261_ FFLHL 266_ IFYIS 271_ CPQNP 276_ YCVCF 281_ MSHFN 286_ LYLIL 291_ IMCNS 296_ IIDPL 301_ IYALR 306_ SQELR 311_ KTFKE 316_ IICCY 321_ PLGGL 326_CDLSS
1: Hormone receptor that acts as a key component of the leptin-melanocortin pathway at the intersection of homeostatic maintenance of energetic state (PubMed:32327598, PubMed:33858992). Plays a role in regulating food intake: activation by a stimulating hormone such as anorexigenic alpha-melanocyte stimulating hormone (alpha-MSH) inhibits appetite, whereas binding to a natural antagonist like Agouti-related protein/AGRP promotes appetite. G-protein-coupled receptor that activates conventional Galphas signaling leading to induction of anorexogenic signaling in the hypothalamus to result in negative energy balance (PubMed:33858992). Regulates the firing activity of neurons from the hypothalamus by alpha-MSH and AGRP independently of Galphas signaling by ligand-induced coupling of closure of inwardly rectifying potassium channel KCNJ13 (By similarity). In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via nesfatin-1/NUCB2 leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion in the intestinal epithelium (PubMed:39562740)