C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191)
1_METPN 6_ TTEDY 11_ DTTTE 16_ FDYGD 21_ ATPCQ 26_ KVNER 31_ AFGAQ 36_ LLPPL 41_ YSLVF 46_ VIGLV 51_ GNILV 56_ VLVLV 61_ QYKRL 66_ KNMTS 71_ IYLLN 76_ LAISD 81_ LLFLF 86_ TLPFW 91_ IDYKL 96_ KDDWV 101_ FGDAM 106_ CKILS 111_ GFYYT 116_ GLYSE 121_ IFFII 126_ LLTID 131_ RYLAI 136_ VHAVF 141_ ALRAR 146_ TVTFG 151_ VITSI 156_ IIWAL 161_ AILAS 166_ MPGLY 171_ FSKTQ 176_ WEFTH 181_ HTCSL 186_ HFPHE 191_ SLREW 196_ KLFQA 201_ LKLNL 206_ FGLVL 211_ PLLVM 216_ IICYT 221_ GIIKI 226_ LLRRP 231_ NEKKS 236_ KAVRL 241_ IFVIM 246_ IIFFL 251_ FWTPY 256_ NLTIL 261_ ISVFQ 266_ DFLFT 271_ HECEQ 276_ SRHLD 281_ LAVQV 286_ TEVIA 291_ YTHCC 296_ VNPVI 301_ YAFVG 306_ ERFRK 311_ YLRQL 316_ FHRRV 321_ AVHLV 326_ KWLPF 331_ LSVDR 336_ LERVS 341_ STSPS 346_TGEHE
1: Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity)