G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)
1_MDIQM 6_ ANNFT 11_ PPSAT 16_ PQGND 21_ CDLYA 26_ HHSTA 31_ RIVMP 36_ LHYSL 41_ VFIIG 46_ LVGNL 51_ LALVV 56_ IVQNR 61_ KKINS 66_ TTLYS 71_ TNLVI 76_ SDILF 81_ TTALP 86_ TRIAY 91_ YAMGF 96_ DWRIG 101_ DALCR 106_ ITALV 111_ FYINT 116_ YAGVN 121_ FMTCL 126_ SIDRF 131_ IAVVH 136_ PLRYN 141_ KIKRI 146_ EHAKG 151_ VCIFV 156_ WILVF 161_ AQTLP 166_ LLINP 171_ MSKQE 176_ AERIT 181_ CMEYP 186_ NFEET 191_ KSLPW 196_ ILLGA 201_ CFIGY 206_ VLPLI 211_ IILIC 216_ YSQIC 221_ CKLFR 226_ TAKQN 231_ PLTEK 236_ SGVNK 241_ KALNT 246_ IILII 251_ VVFVL 256_ CFTPY 261_ HVAII 266_ QHMIK 271_ KLRFS 276_ NFLEC 281_ SQRHS 286_ FQISL 291_ HFTVC 296_ LMNFN 301_ CCMDP 306_ FIYFF 311_ ACKGY 316_ KRKVM 321_ RMLKR 326_ QVSVS 331_ ISSAV 336_ KSAPE 341_ ENSRE 346_ MTETQ 351_ MMIHS 356_KSSNG
1: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity)