Neuronal acetylcholine receptor subunit alpha-3
1_MGSGP 6_ LSLPL 11_ ALSPP 16_ RLLLL 21_ LLLSL 26_ LPVAR 31_ ASEAE 36_ HRLFE 41_ RLFED 46_ YNEII 51_ RPVAN 56_ VSDPV 61_ IIHFE 66_ VSMSQ 71_ LVKVD 76_ EVNQI 81_ METNL 86_ WLKQI 91_ WNDYK 96_ LKWNP 101_ SDYGG 106_ AEFMR 111_ VPAQK 116_ IWKPD 121_ IVLYN 126_ NAVGD 131_ FQVDD 136_ KTKAL 141_ LKYTG 146_ EVTWI 151_ PPAIF 156_ KSSCK 161_ IDVTY 166_ FPFDY 171_ QNCTM 176_ KFGSW 181_ SYDKA 186_ KIDLV 191_ LIGSS 196_ MNLKD 201_ YWESG 206_ EWAII 211_ KAPGY 216_ KHDIK 221_ YNCCE 226_ EIYPD 231_ ITYSL 236_ YIRRL 241_ PLFYT 246_ INLII 251_ PCLLI 256_ SFLTV 261_ LVFYL 266_ PSDCG 271_ EKVTL 276_ CISVL 281_ LSLTV 286_ FLLVI 291_ TETIP 296_ STSLV 301_ IPLIG 306_ EYLLF 311_ TMIFV 316_ TLSIV 321_ ITVFV 326_ LNVHY 331_ RTPTT 336_ HTMPS 341_ WVKTV 346_ FLNLL 351_ PRVMF 356_ MTRPT 361_ SNEGN 366_ AQKPR 371_ PLYGA 376_ ELSNL 381_ NCFSR 386_ AESKG 391_ CKEGY 396_ PCQDG 401_ MCGYC 406_ HHRRI 411_ KISNF 416_ SANLT 421_ RSSSS 426_ ESVDA 431_ VLSLS 436_ ALSPE 441_ IKEAI 446_ QSVKY 451_ IAENM 456_ KAQNE 461_ AKEIQ 466_ DDWKY 471_ VAMVI 476_ DRIFL 481_ WVFTL 486_ VCILG 491_ TAGLF 496_LQPLM
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:31488329, PubMed:31708116). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, with CHRNA5, and CHRNB3 as accesory subunits (PubMed:20881005, PubMed:8663494). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (By similarity)