G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)
1_MELEN 6_ IVANS 11_ LLLKA 16_ RQGGY 21_ GKKSG 26_ RSKKW 31_ KEILT 36_ LPPVS 41_ QCSEL 46_ RHSIE 51_ KDYSS 56_ LCDKQ 61_ PIGRR 66_ LFRQF 71_ CDTKP 76_ TLKRH 81_ IEFLD 86_ AVAEY 91_ EVADD 96_ EDRSD 101_ CGLSI 106_ LDRFF 111_ NDKLA 116_ APLPE 121_ IPPDV 126_ VTECR 131_ LGLKE 136_ ENPSK 141_ KAFEE 146_ CTRVA 151_ HNYLR 156_ GEPFE 161_ EYQES 166_ SYFSQ 171_ FLQWK 176_ WLERQ 181_ PVTKN 186_ TFRHY 191_ RVLGK 196_ GGFGE 201_ VCACQ 206_ VRATG 211_ KMYAC 216_ KKLQK 221_ KRIKK 226_ RKGEA 231_ MALNE 236_ KRILE 241_ KVQSR 246_ FVVSL 251_ AYAYE 256_ TKDAL 261_ CLVLT 266_ IMNGG 271_ DLKFH 276_ IYNLG 281_ NPGFD 286_ EQRAV 291_ FYAAE 296_ LCCGL 301_ EDLQR 306_ ERIVY 311_ RDLKP 316_ ENILL 321_ DDRGH 326_ IRISD 331_ LGLAT 336_ EIPEG 341_ QRVRG 346_ RVGTV 351_ GYMAP 356_ EVVNN 361_ EKYTF 366_ SPDWW 371_ GLGCL 376_ IYEMI 381_ QGHSP 386_ FKKYK 391_ EKVKW 396_ EEVDQ 401_ RIKND 406_ TEEYS 411_ EKFSE 416_ DAKSI 421_ CRMLL 426_ TKNPS 431_ KRLGC 436_ RGEGA 441_ AGVKQ 446_ HPVFK 451_ DINFR 456_ RLEAN 461_ MLEPP 466_ FCPDP 471_ HAVYC 476_ KDVLD 481_ IEQFS 486_ VVKGI 491_ YLDTA 496_ DEDFY 501_ ARFAT 506_ GCVSI 511_ PWQNE 516_ MIESG 521_ CFKDI 526_ NKSES 531_ EEALP 536_ LDLDK 541_ NIHTP 546_ VSRPN 551_ RGFFY 556_ RLFRR 561_ GGCLT 566_ MVPSE 571_KEVEP
1: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2