Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)
1_MSEVS 6_ CKKRD 11_ DYLEW 16_ PEYFM 21_ AVAFL 26_ SAQRS 31_ KDPNS 36_ QVGAC 41_ IVNSE 46_ NKIVG 51_ IGYNG 56_ MPNGC 61_ SDDVL 66_ PWRRT 71_ AENKL 76_ DTKYP 81_ YVCHA 86_ ELNAI 91_ MNKNS 96_ TDVKG 101_ CSMYV 106_ ALFPC 111_ NECAK 116_ LIIQA 121_ GIKEV 126_ IFMSD 131_ KYHDS 136_ DEATA 141_ ARLLF 146_ NMAGV 151_ TFRKF 156_ IPKCS 161_ KIVID 166_ FDSIN 171_SRPSQ
1: Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS (PubMed:7685356). Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP) (PubMed:33833118)