Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)
1_MSVGF 6_ IGAGQ 11_ LAFAL 16_ AKGFT 21_ AAGVL 26_ AAHKI 31_ MASSP 36_ DMDLA 41_ TVSAL 46_ RKMGV 51_ KLTPH 56_ NKETV 61_ QHSDV 66_ LFLAV 71_ KPHII 76_ PFILD 81_ EIGAD 86_ IEDRH 91_ IVVSC 96_ AAGVT 101_ ISSIE 106_ KKLSA 111_ FRPAP 116_ RVIRC 121_ MTNTP 126_ VVVRE 131_ GATVY 136_ ATGTH 141_ AQVED 146_ GRLME 151_ QLLSS 156_ VGFCT 161_ EVEED 166_ LIDAV 171_ TGLSG 176_ SGPAY 181_ AFTAL 186_ DALAD 191_ GGVKM 196_ GLPRR 201_ LAVRL 206_ GAQAL 211_ LGAAK 216_ MLLHS 221_ EQHPG 226_ QLKDN 231_ VSSPG 236_ GATIH 241_ ALHVL 246_ ESGGF 251_ RSLLI 256_ NAVEA 261_ SCIRT 266_ RELQS 271_ MADQE 276_ QVSPA 281_ AIKKT 286_ ILDKV 291_ KLDSP 296_ AGTAL 301_ SPSGH 306_ TKLLP 311_RSLAP
1: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921)