Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
1_MYNMR 6_ RLSLS 11_ PTFSM 16_ GFHLL 21_ VTVSL 26_ LFSHV 31_ DHVIA 36_ ETEME 41_ GEGNE 46_ TGECT 51_ GSYYC 56_ KKGVI 61_ LPIWE 66_ PQDPS 71_ FGDKI 76_ ARATV 81_ YFVAM 86_ VYMFL 91_ GVSII 96_ ADRFM 101_ SSIEV 106_ ITSQE 111_ KEITI 116_ KKPNG 121_ ETTKT 126_ TVRIW 131_ NETVS 136_ NLTLM 141_ ALGSS 146_ APEIL 151_ LSVIE 156_ VCGHN 161_ FTAGD 166_ LGPST 171_ IVGSA 176_ AFNMF 181_ IIIAL 186_ CVYVV 191_ PDGET 196_ RKIKH 201_ LRVFF 206_ VTAAW 211_ SIFAY 216_ TWLYI 221_ ILSVI 226_ SPGVV 231_ EVWEG 236_ LLTFF 241_ FFPIC 246_ VVFAW 251_ VADRR 256_ LLFYK 261_ YVYKR 266_ YRAGK 271_ QRGMI 276_ IEHEG 281_ DRPSS 286_ KTEIE 291_ MDGKV 296_ VNSHV 301_ ENFLD 306_ GALVL 311_ EVDER 316_ DQDDE 321_ EARRE 326_ MARIL 331_ KELKQ 336_ KHPDK 341_ EIEQL 346_ IELAN 351_ YQVLS 356_ QQQKS 361_ RAFYR 366_ IQATR 371_ LMTGA 376_ GNILK 381_ RHAAD 386_ QARKA 391_ VSMHE 396_ VNTEV 401_ TENDP 406_ VSKIF 411_ FEQGT 416_ YQCLE 421_ NCGTV 426_ ALTII 431_ RRGGD 436_ LTNTV 441_ FVDFR 446_ TEDGT 451_ ANAGS 456_ DYEFT 461_ EGTVV 466_ FKPGD 471_ TQKEI 476_ RVGII 481_ DDDIF 486_ EEDEN 491_ FLVHL 496_ SNVKV 501_ SSEAS 506_ EDGIL 511_ EANHV 516_ STLAC 521_ LGSPS 526_ TATVT 531_ IFDDD 536_ HAGIF 541_ TFEEP 546_ VTHVS 551_ ESIGI 556_ MEVKV 561_ LRTSG 566_ ARGNV 571_ IVPYK 576_ TIEGT 581_ ARGGG 586_ EDFED 591_ TCGEL 596_ EFQND 601_ EIVKT 606_ ISVKV 611_ IDDEE 616_ YEKNK 621_ TFFLE 626_ IGEPR 631_ LVEMS 636_ EKKAL 641_ LLNEL 646_ GGFTI 651_ TGKYL 656_ FGQPV 661_ FRKVH 666_ AREHP 671_ ILSTV 676_ ITIAD 681_ EYDDK 686_ QPLTS 691_ KEEEE 696_ RRIAE 701_ MGRPI 706_ LGEHT 711_ KLEVI 716_ IEESY 721_ EFKST 726_ VDKLI 731_ KKTNL 736_ ALVVG 741_ TNSWR 746_ EQFIE 751_ AITVS 756_ AGEDD 761_ DDDEC 766_ GEEKL 771_ PSCFD 776_ YVMHF 781_ LTVFW 786_ KVLFA 791_ FVPPT 796_ EYWNG 801_ WACFI 806_ VSILM 811_ IGLLT 816_ AFIGD 821_ LASHF 826_ GCTIG 831_ LKDSV 836_ TAVVF 841_ VALGT 846_ SVPDT 851_ FASKV 856_ AATQD 861_ QYADA 866_ SIGNV 871_ TGSNA 876_ VNVFL 881_ GIGVA 886_ WSIAA 891_ IYHAA 896_ NGEQF 901_ KVSPG 906_ TLAFS 911_ VTLFT 916_ IFAFI 921_ NVGVL 926_ LYRRR 931_ PEIGG 936_ ELGGP 941_ RTAKL 946_ LTSCL 951_ FVLLW 956_ LLYIF 961_ FSSLE 966_AYCHI
1: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity)