Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)
1_MAPEI 6_ NLPGP 11_ MSLID 16_ NTKGQ 21_ LVVNP 26_ EALKI 31_ LSAIT 36_ QPVVV 41_ VAIVG 46_ LYRTG 51_ KSYLM 56_ NKLAG 61_ KKNGF 66_ SLGST 71_ VKSHT 76_ KGIWM 81_ WCVPH 86_ PKKPE 91_ HTLVL 96_ LDTEG 101_ LGDIE 106_ KGDNE 111_ NDSWI 116_ FALAI 121_ LLSST 126_ FVYNS 131_ MGTIN 136_ QQAMD 141_ QLHYV 146_ TELTD 151_ RIKAN 156_ SSPGN 161_ NSVDD 166_ SADFV 171_ SFFPA 176_ FVWTL 181_ RDFTL 186_ ELEVD 191_ GEPIT 196_ ADDYL 201_ ELSLK 206_ LRKGT 211_ DKKSK 216_ SFNDP 221_ RLCIR 226_ KFFPK 231_ RKCFV 236_ FDWPA 241_ PKKYL 246_ AHLEQ 251_ LKEEE 256_ LNPDF 261_ IEQVA 266_ EFCSY 271_ ILSHS 276_ NVKTL 281_ SGGIP 286_ VNGPR 291_ LESLV 296_ LTYVN 301_ AISSG 306_ DLPCM 311_ ENAVL 316_ ALAQI 321_ ENSAA 326_ VEKAI 331_ AHYEQ 336_ QMGQK 341_ VQLPT 346_ ETLQE 351_ LLDLH 356_ RDSER 361_ EAIEV 366_ FMKNS 371_ FKDVD 376_ QMFQR 381_ KLGAQ 386_ LEARR 391_ DDFCK 396_ QNSKA 401_ SSDCC 406_ MALLQ 411_ DIFGP 416_ LEEDV 421_ KQGTF 426_ SKPGG 431_ YRLFT 436_ QKLQE 441_ LKNKY 446_ YQVPR 451_ KGIQA 456_ KEVLK 461_ KYLES 466_ KEDVA 471_ DALLQ 476_ TDQSL 481_ SEKEK 486_ AIEVE 491_ RIKAE 496_ SAEAA 501_ KKMLE 506_ EIQKK 511_ NEEMM 516_ EQKEK 521_ SYQEH 526_ VKQLT 531_ EKMER 536_ DRAQL 541_ MAEQE 546_ KTLAL 551_ KLQEQ 556_ ERLLK 561_ EGFEN 566_ ESKRL 571_ QKDIW 576_ DIQMR 581_ SKSLE 586_PICNI
1: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448)