General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)
1_MATSS 6_ EEVLL 11_ IVKKV 16_ RQKKQ 21_ DGALY 26_ LMAER 31_ IAWAP 36_ EGKDR 41_ FTISH 46_ MYADI 51_ KCQKI 56_ SPEGK 61_ AKIQL 66_ QLVLH 71_ AGDTT 76_ NFHFS 81_ NESTA 86_ VKERD 91_ AVKDL 96_ LQQLL 101_ PKFKR 106_ KANKE 111_ LEEKN 116_ RMLQE 121_ DPVLF 126_ QLYKD 131_ LVVSQ 136_ VISAE 141_ EFWAN 146_ RLNVN 151_ ATDSS 156_ STSNH 161_ KQDVG 166_ ISAAF 171_ LADVR 176_ PQTDG 181_ CNGLR 186_ YNLTS 191_ DIIES 196_ IFRTY 201_ PAVKM 206_ KYAEN 211_ VPHNM 216_ TEKEF 221_ WTRFF 226_ QSHYF 231_ HRDRL 236_ NTGSK 241_ DLFAE 246_ CAKID 251_ EKGLK 256_ TMVSL 261_ GVKNP 266_ LLDLT 271_ ALEDK 276_ PLDEG 281_ YGISS 286_ VPSAS 291_ NSKSI 296_ KENSN 301_ AAIIK 306_ RFNHH 311_ SAMVL 316_ AAGLR 321_ KQEAQ 326_ NEQTS 331_ EPSNM 336_ DGNSG 341_ DADCF 346_ QPAVK 351_ RAKLQ 356_ ESIEY 361_ EDLGK 366_ NNSVK 371_ TIALN 376_ LKKSD 381_ RYYHG 386_ PTPIQ 391_ SLQYA 396_ TSQDI 401_ INSFQ 406_ SIRQE 411_ MEAYT 416_ PKLTQ 421_ VLSSS 426_ AASST 431_ ITALS 436_ PGGAL 441_ MQGGT 446_ QQAIN 451_ QMVPN 456_ DIQSE 461_ LKHLY 466_ VAVGE 471_ LLRHF 476_ WSCFP 481_ VNTPF 486_ LEEKV 491_ VKMKS 496_ NLERF 501_ QVTKL 506_ CPFQE 511_ KIRRQ 516_ YLSTN 521_ LVSHI 526_ EEMLQ 531_ TAYNK 536_ LHTWQ 541_SRRLM
1: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription