Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6)
1_MMGLF 6_ PRTTG 11_ ALAIF 16_ VVVIL 21_ VHGEL 26_ RIETK 31_ GQYDE 36_ EEMTM 41_ QQAKR 46_ RQKRE 51_ WVKFA 56_ KPCRE 61_ GEDNS 66_ KRNPI 71_ AKITS 76_ DYQAT 81_ QKITY 86_ RISGV 91_ GIDQP 96_ PFGIF 101_ VVDKN 106_ TGDIN 111_ ITAIV 116_ DREET 121_ PSFLI 126_ TCRAL 131_ NAQGL 136_ DVEKP 141_ LILTV 146_ KILDI 151_ NDNPP 156_ VFSQQ 161_ IFMGE 166_ IEENS 171_ ASNSL 176_ VMILN 181_ ATDAD 186_ EPNHL 191_ NSKIA 196_ FKIVS 201_ QEPAG 206_ TPMFL 211_ LSRNT 216_ GEVRT 221_ LTNSL 226_ DREQA 231_ SSYRL 236_ VVSGA 241_ DKDGE 246_ GLSTQ 251_ CECNI 256_ KVKDV 261_ NDNFP 266_ MFRDS 271_ QYSAR 276_ IEENI 281_ LSSEL 286_ LRFQV 291_ TDLDE 296_ EYTDN 301_ WLAVY 306_ FFTSG 311_ NEGNW 316_ FEIQT 321_ DPRTN 326_ EGILK 331_ VVKAL 336_ DYEQL 341_ QSVKL 346_ SIAVK 351_ NKAEF 356_ HQSVI 361_ SRYRV 366_ QSTPV 371_ TIQVI 376_ NVREG 381_ IAFRP 386_ ASKTF 391_ TVQKG 396_ ISSKK 401_ LVDYI 406_ LGTYQ 411_ AIDED 416_ TNKAA 421_ SNVKY 426_ VMGRN 431_ DGGYL 436_ MIDSK 441_ TAEIK 446_ FVKNM 451_ NRDST 456_ FIVNK 461_ TITAE 466_ VLAID 471_ EYTGK 476_ TSTGT 481_ VYVRV 486_ PDFND 491_ NCPTA 496_ VLEKD 501_ AVCSS 506_ SPSVV 511_ VSART 516_ LNNRY 521_ TGPYT 526_ FALED 531_ QPVKL 536_ PAVWS 541_ ITTLN 546_ ATSAL 551_ LRAQE 556_ QIPPG 561_ VYHIS 566_ LVLTD 571_ SQNNR 576_ CEMPR 581_ SLTLE 586_ VCQCD 591_ NRGIC 596_ GTSYP 601_ TTSPG 606_ TRYGR 611_ PHSGR 616_ LGPAA 621_ IGLLL 626_ LGLLL 631_ LLLAP 636_ LLLLT 641_ CDCGA 646_ GSTGG 651_ VTGGF 656_ IPVPD 661_ GSEGT 666_ IHQWG 671_ IEGAH 676_ PEDKE 681_ ITNIC 686_ VPPVT 691_ ANGAD 696_ FMESS 701_ EVCTN 706_ TYARG 711_ TAVEG 716_ TSGME 721_ MTTKL 726_ GAATE 731_ SGGAA 736_ GFATG 741_ TVSGA 746_ ASGFG 751_ AATGV 756_ GICSS 761_ GQSGT 766_ MRTRH 771_ STGGT 776_ NKDYA 781_ DGAIS 786_ MNFLD 791_ SYFSQ 796_ KAFAC 801_ AEEDD 806_ GQEAN 811_ DCLLI 816_ YDNEG 821_ ADATG 826_ SPVGS 831_ VGCCS 836_ FIADD 841_ LDDSF 846_ LDSLG 851_ PKFKK 856_ LAEIS 861_ LGVDG 866_ EGKEV 871_ QPPSK 876_ DSGYG 881_ IESCG 886_ HPIEV 891_ QQTGF 896_ VKCQT 901_ LSGSQ 906_ GASAL 911_ STSGS 916_ VQPAV 921_ SIPDP 926_ LQHGN 931_ YLVTE 936_ TYSAS 941_ GSLVQ 946_ PSTAG 951_ FDPLL 956_ TQNVI 961_ VTERV 966_ ICPIS 971_ SVPGN 976_ LAGPT 981_ QLRGS 986_ HTMLC 991_TEDPC
1: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:31835537). Required for adherens and desmosome junction assembly in response to mechanical force in keratinocytes (PubMed:31835537). Required for desmosome-mediated cell-cell adhesion of cells surrounding the telogen hair club and the basal layer of the outer root sheath epithelium, consequently is essential for the anchoring of telogen hairs in the hair follicle (PubMed:9701552). Required for the maintenance of the epithelial barrier via promoting desmosome-mediated intercellular attachment of suprabasal epithelium to basal cells (By similarity). May play a role in the protein stability of the desmosome plaque components DSP, JUP, PKP1, PKP2 and PKP3 (PubMed:22294297). Required for YAP1 localization at the plasma membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, PKP1 and YWHAG (PubMed:31835537). May also be involved in the positive regulation of YAP1 target gene transcription and as a result cell proliferation (PubMed:31835537). Positively regulates cellular contractility and cell junction formation via organization of cortical F-actin bundles and anchoring of actin to tight junctions, in conjunction with RAC1 (PubMed:22796473). The cytoplasmic pool of DSG3 is required for the localization of CDH1 and CTNNB1 at developing adherens junctions, potentially via modulation of SRC activity (PubMed:22294297). Inhibits keratinocyte migration via suppression of p38MAPK signaling, may therefore play a role in moderating wound healing (PubMed:26763450)