Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
1_MVLAQ 6_ GLLSM 11_ ALLAL 16_ CWERS 21_ LAGAE 26_ ETIPL 31_ QTLRC 36_ YNDYT 41_ SHITC 46_ RWADT 51_ QDAQR 56_ LVNVT 61_ LIRRV 66_ NEDLL 71_ EPVSC 76_ DLSDD 81_ MPWSA 86_ CPHPR 91_ CVPRR 96_ CVIPC 101_ QSFVV 106_ TDVDY 111_ FSFQP 116_ DRPLG 121_ TRLTV 126_ TLTQH 131_ VQPPE 136_ PRDLQ 141_ ISTDQ 146_ DHFLL 151_ TWSVA 156_ LGSPQ 161_ SHWLS 166_ PGDLE 171_ FEVVY 176_ KRLQD 181_ SWEDA 186_ AILLS 191_ NTSQA 196_ TLGPE 201_ HLMPS 206_ STYVA 211_ RVRTR 216_ LAPGS 221_ RLSGR 226_ PSKWS 231_ PEVCW 236_ DSQPG 241_ DEAQP 246_ QNLEC 251_ FFDGA 256_ AVLSC 261_ SWEVR 266_ KEVAS 271_ SVSFG 276_ LFYKP 281_ SPDAG 286_ EEECS 291_ PVLRE 296_ GLGSL 301_ HTRHH 306_ CQIPV 311_ PDPAT 316_ HGQYI 321_ VSVQP 326_ RRAEK 331_ HIKSS 336_ VNIQM 341_ APPSL 346_ NVTKD 351_ GDSYS 356_ LRWET 361_ MKMRY 366_ EHIDH 371_ TFEIQ 376_ YRKDT 381_ ATWKD 386_ SKTET 391_ LQNAH 396_ SMALP 401_ ALEPS 406_ TRYWA 411_ RVRVR 416_ TSRTG 421_ YNGIW 426_ SEWSE 431_ ARSWD 436_ TESVL 441_ PMWVL 446_ ALIVI 451_ FLTIA 456_ VLLAL 461_ RFCGI 466_ YGYRL 471_ RRKWE 476_ EKIPN 481_ PSKSH 486_ LFQNG 491_ SAELW 496_ PPGSM 501_ SAFTS 506_ GSPPH 511_ QGPWG 516_ SRFPE 521_ LEGVF 526_ PVGFG 531_ DSEVS 536_ PLTIE 541_ DPKHV 546_ CDPPS 551_ GPDTT 556_ PAASD 561_ LPTEQ 566_ PPSPQ 571_ PGPPA 576_ ASHTP 581_ EKQAS 586_ SFDFN 591_ GPYLG 596_ PPHSR 601_ SLPDI 606_ LGQPE 611_ PPQEG 616_ GSQKS 621_ PPPGS 626_ LEYLC 631_ LPAGG 636_ QVQLV 641_ PLAQA 646_ MGPGQ 651_ AVEVE 656_ RRPSQ 661_ GAAGS 666_ PSLES 671_ GGGPA 676_ PPALG 681_ PRVGG 686_ QDQKD 691_ SPVAI 696_ PMSSG 701_ DTEDP 706_ GVASG 711_ YVSSA 716_ DLVFT 721_ PNSGA 726_ SSVSL 731_ VPSLG 736_ LPSDQ 741_ TPSLC 746_ PGLAS 751_ GPPGA 756_ PGPVK 761_ SGFEG 766_ YVELP 771_ PIEGR 776_ SPRSP 781_ RNNPV 786_ PPEAK 791_ SPVLN 796_ PGERP 801_ ADVSP 806_ TSPQP 811_ EGLLV 816_ LQQVG 821_ DYCFL 826_ PGLGP 831_ GPLSL 836_ RSKPS 841_ SPGPG 846_ PEIKN 851_ LDQAF 856_ QVKKP 861_ PGQAV 866_ PQVPV 871_ IQLFK 876_ ALKQQ 881_ DYLSL 886_ PPWEV 891_NKPGE
1: Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124)