MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)
1_MRCLA 6_ PRPAG 11_ SYLSE 16_ PQGSS 21_ QCATM 26_ ELGPL 31_ EGGYL 36_ ELLNS 41_ DADPL 46_ CLYHF 51_ YDQMD 56_ LAGEE 61_ EIELY 66_ SEPDT 71_ DTINC 76_ DQFSR 81_ LLCDM 86_ EGDEE 91_ TREAY 96_ ANIAE 101_ LDQYV 106_ FQDSQ 111_ LEGLS 116_ KDIFK 121_ HIGPD 126_ EVIGE 131_ SMEMP 136_ AEVGQ 141_ KSQKR 146_ PFPEE 151_ LPADL 156_ KHWKP 161_ AEPPT 166_ VVTGS 171_ LLVRP 176_ VSDCS 181_ TLPCL 186_ PLPAL 191_ FNQEP 196_ ASGQM 201_ RLEKT 206_ DQIPM 211_ PFSSS 216_ SLSCL 221_ NLPEG 226_ PIQFV 231_ PTIST 236_ LPHGL 241_ WQISE 246_ AGTGV 251_ SSIFI 256_ YHGEV 261_ PQASQ 266_ VPPPS 271_ GFTVH 276_ GLPTS 281_ PDRPG 286_ STSPF 291_ APSAT 296_ DLPSM 301_ PEPAL 306_ TSRAN 311_ MTEHK 316_ TSPTQ 321_ CPAAG 326_ EVSNK 331_ LPKWP 336_ EPVEQ 341_ FYRSL 346_ QDTYG 351_ AEPAG 356_ PDGIL 361_ VEVDL 366_ VQARL 371_ ERSSS 376_ KSLER 381_ ELATP 386_ DWAER 391_ QLAQG 396_ GLAEV 401_ LLAAK 406_ EHRRP 411_ RETRV 416_ IAVLG 421_ KAGQG 426_ KSYWA 431_ GAVSR 436_ AWACG 441_ RLPQY 446_ DFVFS 451_ VPCHC 456_ LNRPG 461_ DAYGL 466_ QDLLF 471_ SLGPQ 476_ PLVAA 481_ DEVFS 486_ HILKR 491_ PDRVL 496_ LILDG 501_ FEELE 506_ AQDGF 511_ LHSTC 516_ GPAPA 521_ EPCSL 526_ RGLLA 531_ GLFQK 536_ KLLRG 541_ CTLLL 546_ TARPR 551_ GRLVQ 556_ SLSKA 561_ DALFE 566_ LSGFS 571_ MEQAQ 576_ AYVMR 581_ YFESS 586_ GMTEH 591_ QDRAL 596_ TLLRD 601_ RPLLL 606_ SHSHS 611_ PTLCR 616_ AVCQL 621_ SEALL 626_ ELGED 631_ AKLPS 636_ TLTGL 641_ YVGLL 646_ GRAAL 651_ DSPPG 656_ ALAEL 661_ AKLAW 666_ ELGRR 671_ HQSTL 676_ QEDQF 681_ PSADV 686_ RTWAM 691_ AKGLV 696_ QHPPR 701_ AAESE 706_ LAFPS 711_ FLLQC 716_ FLGAL 721_ WLALS 726_ GEIKD 731_ KELPQ 736_ YLALT 741_ PRKKR 746_ PYDNW 751_ LEGVP 756_ RFLAG 761_ LIFQP 766_ PARCL 771_ GALLG 776_ PSAAA 781_ SVDRK 786_ QKVLA 791_ RYLKR 796_ LQPGT 801_ LRARQ 806_ LLELL 811_ HCAHE 816_ AEEAG 821_ IWQHV 826_ VQELP 831_ GRLSF 836_ LGTRL 841_ TPPDA 846_ HVLGK 851_ ALEAA 856_ GQDFS 861_ LDLRS 866_ TGICP 871_ SGLGS 876_ LVGLS 881_ CVTRF 886_ RAALS 891_ DTVAL 896_ WESLQ 901_ QHGET 906_ KLLQA 911_ AEEKF 916_ TIEPF 921_ KAKSL 926_ KDVED 931_ LGKLV 936_ QTQRT 941_ RSSSE 946_ DTAGE 951_ LPAVR 956_ DLKKL 961_ EFALG 966_ PVSGP 971_ QAFPK 976_ LVRIL 981_ TAFSS 986_ LQHLD 991_ LDALS 996_ ENKIG 1001_ DEGVS 1006_ QLSAT 1011_ FPQLK 1016_ SLETL 1021_ NLSQN 1026_ NITDL 1031_ GAYKL 1036_ AEALP 1041_ SLAAS 1046_ LLRLS 1051_ LYNNC 1056_ ICDVG 1061_ AESLA 1066_ RVLPD 1071_ MVSLR 1076_ VMDVQ 1081_ YNKFT 1086_ AAGAQ 1091_ QLAAS 1096_ LRRCP 1101_ HVETL 1106_ AMWTP 1111_ TIPFS 1116_ VQEHL 1121_QQQDS
1: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Does not bind DNA (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984, (PubMed:16600381, PubMed:17493635). Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (PubMed:16600381, PubMed:17493635, PubMed:7749984, PubMed:8402893). Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription (PubMed:32855215). Exhibits intrinsic GTP-stimulated acetyltransferase activity (PubMed:11172716). Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro) (PubMed:24036077). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion (PubMed:32855215)
2: Exhibits dominant-negative suppression of MHC class II gene expression