Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)
1_MQAHE 6_ LFRYF 11_ RMPEL 16_ VDFRQ 21_ YVRTL 26_ PTNTL 31_ MGFGA 36_ FAALT 41_ TFWYA 46_ TRPKP 51_ LKPPC 56_ DLSMQ 61_ SVEVA 66_ GSGGA 71_ RRSAL 76_ LDSDE 81_ PLVYF 86_ YDDVT 91_ TLYEG 96_ FQRGI 101_ QVSNN 106_ GPCLG 111_ SRKPD 116_ QPYEW 121_ LSYKQ 126_ VAELS 131_ ECIGS 136_ ALIQK 141_ GFKTA 146_ PDQFI 151_ GIFAQ 156_ NRPEW 161_ VIIEQ 166_ GCFAY 171_ SMVIV 176_ PLYDT 181_ LGNEA 186_ ITYIV 191_ NKAEL 196_ SLVFV 201_ DKPEK 206_ AKLLL 211_ EGVEN 216_ KLIPG 221_ LKIIV 226_ VMDAY 231_ GSELV 236_ ERGQR 241_ CGVEV 246_ TSMKA 251_ MEDLG 256_ RANRR 261_ KPKPP 266_ APEDL 271_ AVICF 276_ TSGTT 281_ GNPKG 286_ AMVTH 291_ RNIVS 296_ DCSAF 301_ VKATE 306_ NTVNP 311_ CPDDT 316_ LISFL 321_ PLAHM 326_ FERVV 331_ ECVML 336_ CHGAK 341_ IGFFQ 346_ GDIRL 351_ LMDDL 356_ KVLQP 361_ TVFPV 366_ VPRLL 371_ NRMFD 376_ RIFGQ 381_ ANTTL 386_ KRWLL 391_ DFASK 396_ RKEAE 401_ LRSGI 406_ IRNNS 411_ LWDRL 416_ IFHKV 421_ QSSLG 426_ GRVRL 431_ MVTGA 436_ APVSA 441_ TVLTF 446_ LRAAL 451_ GCQFY 456_ EGYGQ 461_ TECTA 466_ GCCLT 471_ MPGDW 476_ TAGHV 481_ GAPMP 486_ CNLIK 491_ LVDVE 496_ EMNYM 501_ AAEGE 506_ GEVCV 511_ KGPNV 516_ FQGYL 521_ KDPAK 526_ TAEAL 531_ DKDGW 536_ LHTGD 541_ IGKWL 546_ PNGTL 551_ KIIDR 556_ KKHIF 561_ KLAQG 566_ EYIAP 571_ EKIEN 576_ IYMRS 581_ EPVAQ 586_ VFVHG 591_ ESLQA 596_ FLIAI 601_ VVPDV 606_ ETLCS 611_ WAQKR 616_ GFEGS 621_ FEELC 626_ RNKDV 631_ KKAIL 636_ EDMVR 641_ LGKDS 646_ GLKPF 651_ EQVKG 656_ ITLHP 661_ ELFSI 666_ DNGLL 671_ TPTMK 676_ AKRPE 681_ LRNYF 686_ RSQID 691_DLYST
1: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity)