Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
1_MQRLM 6_ MLLAT 11_ SGACL 16_ GLLAV 21_ AAVAA 26_ AGANP 31_ AQRDT 36_ HSLLP 41_ THRRQ 46_ KRDWI 51_ WNQMH 56_ IDEEK 61_ NTSLP 66_ HHVGK 71_ IKSSV 76_ SRKNA 81_ KYLLK 86_ GEYVG 91_ KVFRV 96_ DAETG 101_ DVFAI 106_ ERLDR 111_ ENISE 116_ YHLTA 121_ VIVDK 126_ DTGEN 131_ LETPS 136_ SFTIK 141_ VHDVN 146_ DNWPV 151_ FTHRL 156_ FNASV 161_ PESSA 166_ VGTSV 171_ ISVTA 176_ VDADD 181_ PTVGD 186_ HASVM 191_ YQILK 196_ GKEYF 201_ AIDNS 206_ GRIIT 211_ ITKSL 216_ DREKQ 221_ ARYEI 226_ VVEAR 231_ DAQGL 236_ RGDSG 241_ TATVL 246_ VTLQD 251_ INDNF 256_ PFFTQ 261_ TKYTF 266_ VVPED 271_ TRVGT 276_ SVGSL 281_ FVEDP 286_ DEPQN 291_ RMTKY 296_ SILRG 301_ DYQDA 306_ FTIET 311_ NPAHN 316_ EGIIK 321_ PMKPL 326_ DYEYI 331_ QQYSF 336_ IVEAT 341_ DPTID 346_ LRYMS 351_ PPAGN 356_ RAQVI 361_ INITD 366_ VDEPP 371_ IFQQP 376_ FYHFQ 381_ LKENQ 386_ KKPLI 391_ GTVLA 396_ MDPDA 401_ ARHSI 406_ GYSIR 411_ RTSDK 416_ GQFFR 421_ VTKKG 426_ DIYNE 431_ KELDR 436_ EVYPW 441_ YNLTV 446_ EAKEL 451_ DSTGT 456_ PTGKE 461_ SIVQV 466_ HIEVL 471_ DENDN 476_ APEFA 481_ KPYQP 486_ KVCEN 491_ AVHGQ 496_ LVLQI 501_ SAIDK 506_ DITPR 511_ NVKFK 516_ FILNT 521_ ENNFT 526_ LTDNH 531_ DNTAN 536_ ITVKY 541_ GQFDR 546_ EHTKV 551_ HFLPV 556_ VISDN 561_ GMPSR 566_ TGTST 571_ LTVAV 576_ CKCNE 581_ QGEFT 586_ FCEDM 591_ AAQVG 596_ VSIQA 601_ VVAIL 606_ LCILT 611_ ITVIT 616_ LLIFL 621_ RRRLR 626_ KQARA 631_ HGKSV 636_ PEIHE 641_ QLVTY 646_ DEEGG 651_ GEMDT 656_ TSYDV 661_ SVLNS 666_ VRRGG 671_ AKPPR 676_ PALDA 681_ RPSLY 686_ AQVQK 691_ PPRHA 696_ PGAHG 701_ GPGEM 706_ AAMIE 711_ VKKDE 716_ ADHDG 721_ DGPPY 726_ DTLHI 731_ YGYEG 736_ SESIA 741_ ESLSS 746_ LGTDS 751_ SDSDV 756_ DYDFL 761_ NDWGP 766_ RFKML 771_ AELYG 776_SDPRE
1: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (By similarity)