Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c)
1_MDPAV 6_ ALVLC 11_ LSCLF 16_ LLSLW 21_ RQSSG 26_ RGRLP 31_ SGPTP 36_ LPIIG 41_ NILQL 46_ DVKDM 51_ SKSLT 56_ NFSKV 61_ YGPVF 66_ TVYFG 71_ LKPIV 76_ VLHGY 81_ EAVKE 86_ ALIDH 91_ GEEFS 96_ GRGSF 101_ PVAEK 106_ VNKGL 111_ GILFS 116_ NGKRW 121_ KEIRR 126_ FCLMT 131_ LRNFG 136_ MGKRS 141_ IEDRV 146_ QEEAR 151_ CLVEE 156_ LRKTN 161_ ASPCD 166_ PTFIL 171_ GCAPC 176_ NVICS 181_ VIFHD 186_ RFDYK 191_ DQRFL 196_ NLMEK 201_ FNENL 206_ RILSS 211_ PWIQV 216_ CNNFP 221_ ALIDY 226_ LPGSH 231_ NKIAE 236_ NFAYI 241_ KSYVL 246_ ERIKE 251_ HQESL 256_ DMNSA 261_ RDFID 266_ CFLIK 271_ MEQEK 276_ HNQQS 281_ EFTVE 286_ SLIAT 291_ VTDMF 296_ GAGTE 301_ TTSTT 306_ LRYGL 311_ LLLLK 316_ YPEVT 321_ AKVQE 326_ EIECV 331_ VGRNR 336_ SPCMQ 341_ DRSHM 346_ PYTDA 351_ VVHEI 356_ QRYID 361_ LLPTN 366_ LPHAV 371_ TCDVK 376_ FKNYL 381_ IPKGT 386_ TIITS 391_ LTSVL 396_ HNDKE 401_ FPNPE 406_ MFDPG 411_ HFLDK 416_ SGNFK 421_ KSDYF 426_ MPFSA 431_ GKRMC 436_ MGEGL 441_ ARMEL 446_ FLFLT 451_ TILQN 456_ FNLKS 461_ QVDPK 466_ DIDIT 471_ PIANA 476_ FGRVP 481_PLYQL
1: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)