Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
1_MDPFV 6_ VLVLC 11_ LSCLL 16_ LLSIW 21_ RQSSG 26_ RGKLP 31_ PGPTP 36_ LPVIG 41_ NILQI 46_ DIKDV 51_ SKSLT 56_ NLSKI 61_ YGPVF 66_ TLYFG 71_ LERMV 76_ VLHGY 81_ EVVKE 86_ ALIDL 91_ GEEFS 96_ GRGHF 101_ PLAER 106_ ANRGF 111_ GIVFS 116_ NGKRW 121_ KEIRR 126_ FSLMT 131_ LRNFG 136_ MGKRS 141_ IEDRV 146_ QEEAR 151_ CLVEE 156_ LRKTK 161_ ASPCD 166_ PTFIL 171_ GCAPC 176_ NVICS 181_ IIFQK 186_ RFDYK 191_ DQQFL 196_ NLMEK 201_ LNENI 206_ RIVST 211_ PWIQI 216_ CNNFP 221_ TIIDY 226_ FPGTH 231_ NKLLK 236_ NLAFM 241_ ESDIL 246_ EKVKE 251_ HQESM 256_ DINNP 261_ RDFID 266_ CFLIK 271_ MEKEK 276_ QNQQS 281_ EFTIE 286_ NLVIT 291_ AADLL 296_ GAGTE 301_ TTSTT 306_ LRYAL 311_ LLLLK 316_ HPEVT 321_ AKVQE 326_ EIERV 331_ IGRNR 336_ SPCMQ 341_ DRGHM 346_ PYTDA 351_ VVHEV 356_ QRYID 361_ LIPTS 366_ LPHAV 371_ TCDVK 376_ FRNYL 381_ IPKGT 386_ TILTS 391_ LTSVL 396_ HDNKE 401_ FPNPE 406_ MFDPR 411_ HFLDE 416_ GGNFK 421_ KSNYF 426_ MPFSA 431_ GKRIC 436_ VGEGL 441_ ARMEL 446_ FLFLT 451_ FILQN 456_ FNLKS 461_ LIDPK 466_ DLDTT 471_ PVVNG 476_ FASVP 481_PFYQL
1: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:19965576, PubMed:20972997). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307)