Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
1_MTPLC 6_ PRPAL 11_ CYHFL 16_ TSLLR 21_ SAMQN 26_ ARGAR 31_ QRAEA 36_ AVLSG 41_ PGPPL 46_ GRAAQ 51_ HGIPR 56_ PLSSA 61_ GRLSQ 66_ GCRGA 71_ STVGA 76_ AGWKG 81_ ELPKA 86_ GGSPA 91_ PGPET 96_ PAISP 101_ SKRAR 106_ PAEVG 111_ GMQLR 116_ FARLS 121_ EHATA 126_ PTRGS 131_ ARAAG 136_ YDLYS 141_ AYDYT 146_ IPPME 151_ KAVVK 156_ TDIQI 161_ ALPSG 166_ CYGRV 171_ APRSG 176_ LAAKH 181_ FIDVG 186_ AGVID 191_ EDYRG 196_ NVGVV 201_ LFNFG 206_ KEKFE 211_ VKKGD 216_ RIAQL 221_ ICERI 226_ FYPEI 231_ EEVQA 236_ LDDTE 241_ RGSGG 246_FGSTG
1: Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity)