Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2)
1_MSRRK 6_ ISSES 11_ FSSLG 16_ SDYLE 21_ TSPEE 26_ EGECP 31_ LSRLC 36_ WNGSR 41_ SPPGP 46_ LEPSP 51_ AAAAA 56_ AAAPA 61_ PTPAA 66_ SAAAA 71_ AATAG 76_ ARRVQ 81_ RRRRV 86_ NLDSL 91_ GESIS 96_ RLTAP 101_ SPQTI 106_ QQTLK 111_ RTLQY 116_ YEHQV 121_ IGYRD 126_ AEKNF 131_ HNISN 136_ RCSYA 141_ DHSNK 146_ EEIED 151_ VSGIL 156_ QCTAN 161_ ILGLK 166_ FEEIQ 171_ KRFGE 176_ EFFNI 181_ CFHEN 186_ ERVLR 191_ AVGGT 196_ LQDFF 201_ NGFDA 206_ LLEHI 211_ RTSFG 216_ KQATL 221_ ESPSF 226_ LCKEL 231_ PEGTL 236_ MLHYF 241_ HPHHI 246_ VGFAM 251_ LGMIK 256_ AAGKK 261_ IYRLD 266_ VEVEQ 271_ VANEK 276_ LCSDV 281_ SNPGN 286_ CSCLT 291_ FLIKE 296_ CENTN 301_ IMKNL 306_ PQGTS 311_ QVPAD 316_ LRISI 321_ NTFCR 326_ AFPFH 331_ LMFDP 336_ SMSVL 341_ QLGEG 346_ LRKQL 351_ RCDTH 356_ KVLKF 361_ EDCFE 366_ IVSPK 371_ VNATF 376_ ERVLL 381_ RLSTP 386_ FVIRT 391_ KPEAS 396_ GSENK 401_ DKVME 406_ VKGQM 411_ IHVPE 416_ SNSIL 421_ FLGSP 426_ CVDKL 431_ DELMG 436_ RGLHL 441_ SDIPI 446_ HDATR 451_ DVILV 456_ GEQAK 461_ AQDGL 466_ KKRMD 471_ KLKAT 476_ LERTH 481_ QALEE 486_ EKKKT 491_ VDLLY 496_ SIFPG 501_ DVAQQ 506_ LWQGQ 511_ QVQAR 516_ KFDDV 521_ TMLFS 526_ DIVGF 531_ TAICA 536_ QCTPM 541_ QVISM 546_ LNELY 551_ TRFDH 556_ QCGFL 561_ DIYKV 566_ ETIGD 571_ AYCVA 576_ AGLHR 581_ KSLCH 586_ AKPIA 591_ LMALK 596_ MMELS 601_ EEVLT 606_ PDGRP 611_ IQMRI 616_ GIHSG 621_ SVLAG 626_ VVGVR 631_ MPRYC 636_ LFGNN 641_ VTLAS 646_ KFESG 651_ SHPRR 656_ INVSP 661_ TTYQL 666_ LKREE 671_ SFTFI 676_ PRSRE 681_ ELPDN 686_ FPKEI 691_ PGICY 696_ FLEVR 701_ TGPKP 706_ PKPSL 711_ SSSRI 716_ KKVSY 721_ NIGTM 726_FLRET
1: Has guanylyl cyclase on binding to the beta-1 subunit
2: Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits