Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)
1_MALRG 6_ FCSAD 11_ GSDPL 16_ WDWNV 21_ TWNTS 26_ NPDFT 31_ KCFQN 36_ TVLVW 41_ VPCFY 46_ LWACF 51_ PFYFL 56_ YLSRH 61_ DRGYI 66_ QMTPL 71_ NKTKT 76_ ALGFL 81_ LWIVC 86_ WADLF 91_ YSFWE 96_ RSRGI 101_ FLAPV 106_ FLVSP 111_ TLLGI 116_ TMLLA 121_ TFLIQ 126_ LERRK 131_ GVQSS 136_ GIMLT 141_ FWLVA 146_ LVCAL 151_ AILRS 156_ KIMTA 161_ LKEDA 166_ QVDLF 171_ RDITF 176_ YVYFS 181_ LLLIQ 186_ LVLSC 191_ FSDRS 196_ PLFSE 201_ TIHDP 206_ NPCPE 211_ SSASF 216_ LSRIT 221_ FWWIT 226_ GLIVR 231_ GYRQP 236_ LEGSD 241_ LWSLN 246_ KEDTS 251_ EQVVP 256_ VLVKN 261_ WKKEC 266_ AKTRK 271_ QPVKV 276_ VYSSK 281_ DPAQP 286_ KESSK 291_ VDANE 296_ EVEAL 301_ IVKSP 306_ QKEWN 311_ PSLFK 316_ VLYKT 321_ FGPYF 326_ LMSFF 331_ FKAIH 336_ DLMMF 341_ SGPQI 346_ LKLLI 351_ KFVND 356_ TKAPD 361_ WQGYF 366_ YTVLL 371_ FVTAC 376_ LQTLV 381_ LHQYF 386_ HICFV 391_ SGMRI 396_ KTAVI 401_ GAVYR 406_ KALVI 411_ TNSAR 416_ KSSTV 421_ GEIVN 426_ LMSVD 431_ AQRFM 436_ DLATY 441_ INMIW 446_ SAPLQ 451_ VILAL 456_ YLLWL 461_ NLGPS 466_ VLAGV 471_ AVMVL 476_ MVPVN 481_ AVMAM 486_ KTKTY 491_ QVAHM 496_ KSKDN 501_ RIKLM 506_ NEILN 511_ GIKVL 516_ KLYAW 521_ ELAFK 526_ DKVLA 531_ IRQEE 536_ LKVLK 541_ KSAYL 546_ SAVGT 551_ FTWVC 556_ TPFLV 561_ ALCTF 566_ AVYVT 571_ IDENN 576_ ILDAQ 581_ TAFVS 586_ LALFN 591_ ILRFP 596_ LNILP 601_ MVISS 606_ IVQAS 611_ VSLKR 616_ LRIFL 621_ SHEEL 626_ EPDSI 631_ ERRPV 636_ KDGGG 641_ TNSIT 646_ VRNAT 651_ FTWAR 656_ SDPPT 661_ LNGIT 666_ FSIPE 671_ GALVA 676_ VVGQV 681_ GCGKS 686_ SLLSA 691_ LLAEM 696_ DKVEG 701_ HVAIK 706_ GSVAY 711_ VPQQA 716_ WIQND 721_ SLREN 726_ ILFGC 731_ QLEEP 736_ YYRSV 741_ IQACA 746_ LLPDL 751_ EILPS 756_ GDRTE 761_ IGEKG 766_ VNLSG 771_ GQKQR 776_ VSLAR 781_ AVYSN 786_ ADIYL 791_ FDDPL 796_ SAVDA 801_ HVGKH 806_ IFENV 811_ IGPKG 816_ MLKNK 821_ TRILV 826_ THSMS 831_ YLPQV 836_ DVIIV 841_ MSGGK 846_ ISEMG 851_ SYQEL 856_ LARDG 861_ AFAEF 866_ LRTYA 871_ STEQE 876_ QDAEE 881_ NGVTG 886_ VSGPG 891_ KEAKQ 896_ MENGM 901_ LVTDS 906_ AGKQL 911_ QRQLS 916_ SSSSY 921_ SGDIS 926_ RHHNS 931_ TAELQ 936_ KAEAK 941_ KEETW 946_ KLMEA 951_ DKAQT 956_ GQVKL 961_ SVYWD 966_ YMKAI 971_ GLFIS 976_ FLSIF 981_ LFMCN 986_ HVSAL 991_ ASNYW 996_ LSLWT 1001_ DDPIV 1006_ NGTQE 1011_ HTKVR 1016_ LSVYG 1021_ ALGIS 1026_ QGIAV 1031_ FGYSM 1036_ AVSIG 1041_ GILAS 1046_ RCLHV 1051_ DLLHS 1056_ ILRSP 1061_ MSFFE 1066_ RTPSG 1071_ NLVNR 1076_ FSKEL 1081_ DTVDS 1086_ MIPEV 1091_ IKMFM 1096_ GSLFN 1101_ VIGAC 1106_ IVILL 1111_ ATPIA 1116_ AIIIP 1121_ PLGLI 1126_ YFFVQ 1131_ RFYVA 1136_ SSRQL 1141_ KRLES 1146_ VSRSP 1151_ VYSHF 1156_ NETLL 1161_ GVSVI 1166_ RAFEE 1171_ QERFI 1176_ HQSDL 1181_ KVDEN 1186_ QKAYY 1191_ PSIVA 1196_ NRWLA 1201_ VRLEC 1206_ VGNCI 1211_ VLFAA 1216_ LFAVI 1221_ SRHSL 1226_ SAGLV 1231_ GLSVS 1236_ YSLQV 1241_ TTYLN 1246_ WLVRM 1251_ SSEME 1256_ TNIVA 1261_ VERLK 1266_ EYSET 1271_ EKEAP 1276_ WQIQE 1281_ TAPPS 1286_ SWPQV 1291_ GRVEF 1296_ RNYCL 1301_ RYRED 1306_ LDFVL 1311_ RHINV 1316_ TINGG 1321_ EKVGI 1326_ VGRTG 1331_ AGKSS 1336_ LTLGL 1341_ FRINE 1346_ SAEGE 1351_ IIIDG 1356_ INIAK 1361_ IGLHD 1366_ LRFKI 1371_ TIIPQ 1376_ DPVLF 1381_ SGSLR 1386_ MNLDP 1391_ FSQYS 1396_ DEEVW 1401_ TSLEL 1406_ AHLKD 1411_ FVSAL 1416_ PDKLD 1421_ HECAE 1426_ GGENL 1431_ SVGQR 1436_ QLVCL 1441_ ARALL 1446_ RKTKI 1451_ LVLDE 1456_ ATAAV 1461_ DLETD 1466_ DLIQS 1471_ TIRTQ 1476_ FEDCT 1481_ VLTIA 1486_ HRLNT 1491_ IMDYT 1496_ RVIVL 1501_ DKGEI 1506_ QEYGA 1511_ PSDLL 1516_ QQRGL 1521_ FYSMA 1526_KDAGL
1: Mediates export of organic anions and drugs from the cytoplasm (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:10064732, PubMed:11114332, PubMed:16230346, PubMed:7961706, PubMed:9281595). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthesizing cells (By similarity). Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769). Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231)