T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
1_MGHTR 6_ RQGTS 11_ PSKCP 16_ YLNFF 21_ QLLVL 26_ AGLSH 31_ FCSGV 36_ IHVTK 41_ EVKEV 46_ ATLSC 51_ GHNVS 56_ VEELA 61_ QTRIY 66_ WQKEK 71_ KMVLT 76_ MMSGD 81_ MNIWP 86_ EYKNR 91_ TIFDI 96_ TNNLS 101_ IVILA 106_ LRPSD 111_ EGTYE 116_ CVVLK 121_ YEKDA 126_ FKREH 131_ LAEVT 136_ LSVKA 141_ DFPTP 146_ SISDF 151_ EIPTS 156_ NIRRI 161_ ICSTS 166_ GGFPE 171_ PHLSW 176_ LENGE 181_ ELNAI 186_ NTTVS 191_ QDPET 196_ ELYAV 201_ SSKLD 206_ FNMTT 211_ NHSFM 216_ CLIKY 221_ GHLRV 226_ NQTFN 231_ WNTTK 236_ QEHFP 241_ DNLLP 246_ SWAIT 251_ LISVN 256_ GIFVI 261_ CCLTY 266_ CFAPR 271_ CRERR 276_ RNERL 281_RRESV
1: Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed:12121659). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity)
2: (Microbial infection) Acts as a receptor for adenovirus subgroup B