ATP-binding cassette sub-family D member 1 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy protein) (ALDP)
1_MPVLS 6_ RPRPW 11_ RGNTL 16_ KRTAV 21_ LLALA 26_ AYGAH 31_ KVYPL 36_ VRQCL 41_ APARG 46_ LQAPA 51_ GEPTQ 56_ EASGV 61_ AAAKA 66_ GMNRV 71_ FLQRL 76_ LWLLR 81_ LLFPR 86_ VLCRE 91_ TGLLA 96_ LHSAA 101_ LVSRT 106_ FLSVY 111_ VARLD 116_ GRLAR 121_ CIVRK 126_ DPRAF 131_ GWQLL 136_ QWLLI 141_ ALPAT 146_ FVNSA 151_ IRYLE 156_ GQLAL 161_ SFRSR 166_ LVAHA 171_ YRLYF 176_ SQQTY 181_ YRVSN 186_ MDGRL 191_ RNPDQ 196_ SLTED 201_ VVAFA 206_ ASVAH 211_ LYSNL 216_ TKPLL 221_ DVAVT 226_ SYTLL 231_ RAARS 236_ RGAGT 241_ AWPSA 246_ IAGLV 251_ VFLTA 256_ NVLRA 261_ FSPKF 266_ GELVA 271_ EEARR 276_ KGELR 281_ YMHSR 286_ VVANS 291_ EEIAF 296_ YGGHE 301_ VELAL 306_ LQRSY 311_ QDLAS 316_ QINLI 321_ LLERL 326_ WYVML 331_ EQFLM 336_ KYVWS 341_ ASGLL 346_ MVAVP 351_ IITAT 356_ GYSES 361_ DAEAV 366_ KKAAL 371_ EKKEE 376_ ELVSE 381_ RTEAF 386_ TIARN 391_ LLTAA 396_ ADAIE 401_ RIMSS 406_ YKEVT 411_ ELAGY 416_ TARVH 421_ EMFQV 426_ FEDVQ 431_ RCHFK 436_ RPREL 441_ EDAQA 446_ GSGTI 451_ GRSGV 456_ RVEGP 461_ LKIRG 466_ QVVDV 471_ EQGII 476_ CENIP 481_ IVTPS 486_ GEVVV 491_ ASLNI 496_ RVEEG 501_ MHLLI 506_ TGPNG 511_ CGKSS 516_ LFRIL 521_ GGLWP 526_ TYGGV 531_ LYKPP 536_ PQRMF 541_ YIPQR 546_ PYMSV 551_ GSLRD 556_ QVIYP 561_ DSVED 566_ MQRKG 571_ YSEQD 576_ LEAIL 581_ DVVHL 586_ HHILQ 591_ REGGW 596_ EAMCD 601_ WKDVL 606_ SGGEK 611_ QRIGM 616_ ARMFY 621_ HRPKY 626_ ALLDE 631_ CTSAV 636_ SIDVE 641_ GKIFQ 646_ AAKDA 651_ GIALL 656_ SITHR 661_ PSLWK 666_ YHTHL 671_ LQFDG 676_ EGGWK 681_ FEKLD 686_ SAARL 691_ SLTEE 696_ KQRLE 701_ QQLAG 706_ IPKMQ 711_ RRLQE 716_ LCQIL 721_ GEAVA 726_ PAHVP 731_ APSPQ 736_GPGGL
1: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed:15682271, PubMed:16946495, PubMed:18757502, PubMed:21145416, PubMed:23671276, PubMed:29397936, PubMed:33500543). Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed:29397936, PubMed:33500543). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:21145416, PubMed:23671276). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity)