Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)
1_MESED 6_ LSGRE 11_ LTIDS 16_ IMNKV 21_ RDIKN 26_ KFKNE 31_ DLTDE 36_ LSLNK 41_ ISADT 46_ TDNSG 51_ TVNQI 56_ MMMAN 61_ NPEDW 66_ LSLLL 71_ KLEKN 76_ SVPLS 81_ DALLN 86_ KLIGR 91_ YSQAI 96_ EALPP 101_ DKYGQ 106_ NESFA 111_ RIQVR 116_ FAELK 121_ AIQEP 126_ DDARD 131_ YFQMA 136_ RANCK 141_ KFAFV 146_ HISFA 151_ QFELS 156_ QGNVK 161_ KSKQL 166_ LQKAV 171_ ERGAV 176_ PLEML 181_ EIALR 186_ NLNLQ 191_ KKQLL 196_ SEEEK 201_ KNLSA 206_ STVLT 211_ AQESF 216_ SGSLG 221_ HLQNR 226_ NNSCD 231_ SRGQT 236_ TKARF 241_ LYGEN 246_ MPPQD 251_ AEIGY 256_ RNSLR 261_ QTNKT 266_ KQSCP 271_ FGRVP 276_ VNLLN 281_ SPDCD 286_ VKTDD 291_ SVVPC 296_ FMKRQ 301_ TSRSE 306_ CRDLV 311_ VPGSK 316_ PSGND 321_ SCELR 326_ NLKSV 331_ QNSHF 336_ KEPLV 341_ SDEKS 346_ SELII 351_ TDSIT 356_ LKNKT 361_ ESSLL 366_ AKLEE 371_ TKEYQ 376_ EPEVP 381_ ESNQK 386_ QWQSK 391_ RKSEC 396_ INQNP 401_ AASSN 406_ HWQIP 411_ ELARK 416_ VNTEQ 421_ KHTTF 426_ EQPVF 431_ SVSKQ 436_ SPPIS 441_ TSKWF 446_ DPKSI 451_ CKTPS 456_ SNTLD 461_ DYMSC 466_ FRTPV 471_ VKNDF 476_ PPACQ 481_ LSTPY 486_ GQPAC 491_ FQQQQ 496_ HQILA 501_ TPLQN 506_ LQVLA 511_ SSSAN 516_ ECISV 521_ KGRIY 526_ SILKQ 531_ IGSGG 536_ SSKVF 541_ QVLNE 546_ KKQIY 551_ AIKYV 556_ NLEEA 561_ DNQTL 566_ DSYRN 571_ EIAYL 576_ NKLQQ 581_ HSDKI 586_ IRLYD 591_ YEITD 596_ QYIYM 601_ VMECG 606_ NIDLN 611_ SWLKK 616_ KKSID 621_ PWERK 626_ SYWKN 631_ MLEAV 636_ HTIHQ 641_ HGIVH 646_ SDLKP 651_ ANFLI 656_ VDGML 661_ KLIDF 666_ GIANQ 671_ MQPDT 676_ TSVVK 681_ DSQVG 686_ TVNYM 691_ PPEAI 696_ KDMSS 701_ SRENG 706_ KSKSK 711_ ISPKS 716_ DVWSL 721_ GCILY 726_ YMTYG 731_ KTPFQ 736_ QIINQ 741_ ISKLH 746_ AIIDP 751_ NHEIE 756_ FPDIP 761_ EKDLQ 766_ DVLKC 771_ CLKRD 776_ PKQRI 781_ SIPEL 786_ LAHPY 791_ VQIQT 796_ HPVNQ 801_ MAKGT 806_ TEEMK 811_ YVLGQ 816_ LVGLN 821_ SPNSI 826_ LKAAK 831_ TLYEH 836_ YSGGE 841_ SHNSS 846_ SSKTF 851_EKKRG
1: Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839)