DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)
1_MSSPA 6_ STPSR 11_ RGSRR 16_ GRATP 21_ AQTPR 26_ SEDAR 31_ SSPSQ 36_ RRRGE 41_ DSTST 46_ GELQP 51_ MPTSP 56_ GVDLQ 61_ SPAAQ 66_ DVLFS 71_ SPPQM 76_ HSSAI 81_ PLDFD 86_ VSSPL 91_ TYGTP 96_ SSRVE 101_ GTPRS 106_ GVRGT 111_ PVRQR 116_ PDLGS 121_ AQKGL 126_ QVDLQ 131_ SDGAA 136_ AEDIV 141_ ASEQS 146_ LGQKL 151_ VIWGT 156_ DVNVA 161_ ACKEN 166_ FQRFL 171_ QRFID 176_ PLAKE 181_ EENVG 186_ IDITE 191_ PLYMQ 196_ RLGEI 201_ NVIGE 206_ PFLNV 211_ NCEHI 216_ KSFDK 221_ NLYRQ 226_ LISYP 231_ QEVIP 236_ TFDMA 241_ VNEIF 246_ FDRYP 251_ DSILE 256_ HQIQV 261_ RPFNA 266_ LKTKN 271_ MRNLN 276_ PEDID 281_ QLITI 286_ SGMVI 291_ RTSQL 296_ IPEMQ 301_ EAFFQ 306_ CQVCA 311_ HTTRV 316_ EMDRG 321_ RIAEP 326_ SVCGR 331_ CHTTH 336_ SMALI 341_ HNRSL 346_ FSDKQ 351_ MIKLQ 356_ ESPED 361_ MPAGQ 366_ TPHTV 371_ ILFAH 376_ NDLVD 381_ KVQPG 386_ DRVNV 391_ TGIYR 396_ AVPIR 401_ VNPRV 406_ SNVKS 411_ VYKTH 416_ IDVIH 421_ YRKTD 426_ AKRLH 431_ GLDEE 436_ AEQKL 441_ FSEKR 446_ VELLK 451_ ELSRK 456_ PDIYE 461_ RLASA 466_ LAPSI 471_ YEHED 476_ IKKGI 481_ LLQLF 486_ GGTRK 491_ DFSHT 496_ GRGKF 501_ RAEIN 506_ ILLCG 511_ DPGTS 516_ KSQLL 521_ QYVYN 526_ LVPRG 531_ QYTSG 536_ KGSSA 541_ VGLTA 546_ YVMKD 551_ PETRQ 556_ LVLQT 561_ GALVL 566_ SDNGI 571_ CCIDE 576_ FDKMN 581_ ESTRS 586_ VLHEV 591_ MEQQT 596_ LSIAK 601_ AGIIC 606_ QLNAR 611_ TSVLA 616_ AANPI 621_ ESQWN 626_ PKKTT 631_ IENIQ 636_ LPHTL 641_ LSRFD 646_ LIFLL 651_ LDPQD 656_ EAYDR 661_ RLAHH 666_ LVALY 671_ YQSEE 676_ QAEEE 681_ LLDMA 686_ VLKDY 691_ IAYAH 696_ STIMP 701_ RLSEE 706_ ASQAL 711_ IEAYV 716_ DMRKI 721_ GSSRG 726_ MVSAY 731_ PRQLE 736_ SLIRL 741_ AEAHA 746_ KVRLS 751_ NKVEA 756_ IDVEE 761_ AKRLH 766_ REALK 771_ QSATD 776_ PRTGI 781_ VDISI 786_ LTTGM 791_ SATSR 796_ KRKEE 801_ LAEAL 806_ KKLIL 811_ SKGKT 816_ PALKY 821_ QQLFE 826_ DIRGQ 831_ SDIAI 836_ TKDMF 841_ EEALR 846_ ALADD 851_ DFLTV 856_TGKTV
1: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914)